记忆力缺损老人向痴呆移行中关联负变化

与年龄有关的记忆力缺损老年人（ＡＡＭＩ）和年龄相匹配的健康老人各２２例分别作为研究组才对照组，行关联负变化（ＣＮＶ）和长谷川痴呆量表（ＨＤＳ）测查；２年后对研究组进行复查，以了解向痴呆发展过程中ＡＡＭＩ的ＣＮＶ特征及变化趋势，结果示，随着认知功能的减退，研究组初为命令信号后负变化（ＰＩＮＶ）面积增大；ＣＮＶ波形不规则，期待波（ＥＷ）不稳定伴压低，ＰＩＮＶ压低。

CONTINGENT NEGATIVE VARIATION IN THE AGED ASSOCIATED WITH MEMORY IMPAIRMENT IN THE COURSE OF DEVELOPMENT TOWARDS DEMENTIA

To investigate the feature and general trend of the contingent negative variation(CNV) in the aged associated with memory impairment(AAMI) in the course of development towards dementia. CNV and Hasegawa's dementia scale for the aged(HDS) in 22 of AAMI (serving as the study group) and 22 of normal elderly subjects selected from well-matched in age (serving as the control group) were examined at first.2 years later,22 of the study group were examined again.The tendency was revealed that the reaction time(RT) was prolonged, and the whole wave of the CNV decreased along with the development of the cognitive dysfunction in the AAMI. The CNV could constitute a valuable means of the electrophysiology for the study of brain function deterioration and useful for dynamically observing the speed of the development towards dementia and severity degree of the dementia in AAMI.