| NGF基因在人骨髓巨核细胞表达的意义探讨 |
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| 引用本文： | 顾静,吴芳颐.NGF基因在人骨髓巨核细胞表达的意义探讨[J].南通医学院学报,1999,19(2):141-143. |
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| 作者姓名： | 顾静 吴芳颐 |
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| 作者单位： | 南通医学院附属医院血液研究室 |
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| 摘 要： | 应用原位分子杂交技术，检测神经生长因子在人骨髓巨核细胞分化发育过程中的基因表达情况，以探讨ＮＧＦ对骨髓造血组织的功能意义。实验结果表明，βＮＧＦ ｃＤＮＡ探针与其互补的ｍＲＮＡ杂交反应信号存在于原巨核细胞，幼巨核细胞，颗粒型巨核细胞，成熟型巨核细胞等各级不同发育阶段的巨核细胞胞浆中，实验结果提示，ＮＧＦ在骨髓巨核细胞系的发育成熟过程中可能发挥调节作用。
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| 关 键 词： | 神经生长因子 巨核细胞 基因表达 骨髓 |
SIGNIFICANCE EXPLORATION OF NERVE GROWTH FACTOR GENE EXPRESSION IN HUMAN BONE MARROW |
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| Gu Jing,Wu Fangyi,Cheng Xiufang.SIGNIFICANCE EXPLORATION OF NERVE GROWTH FACTOR GENE EXPRESSION IN HUMAN BONE MARROW[J].ACTA Academiae Medicinae Nantong,1999,19(2):141-143. |
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| Authors: | Gu Jing Wu Fangyi Cheng Xiufang |
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| Abstract: | Used in situ hybridization method to investigate the expression of nerve growth factor(NGF) gene during development of megalocaryocytes to explore effects of NGF on hematopoietic tissue of human bone marrow.The results showed that the positive hybridized signals were localized in all kinds of megalocaryocytes including megakaryoblast,promegakaryocyte,granular megakaryocyte and thrombocytogenous megakaryocyte.The study suggested that NGF may play an important role in development and maturation of megakaryocyte in bone marrow. |
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| Keywords: | nerve growth factormegakaryocytegene expressionhuman |
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