| 阿霉素心肌病发病机理的实验研究 |
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| 引用本文： | 赵建美,蒋晓天.阿霉素心肌病发病机理的实验研究[J].南通医学院学报,1999,19(2):160-161. |
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| 作者姓名： | 赵建美 蒋晓天 |
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| 作者单位： | 南通医学院附属医院儿科 |
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| 摘 要： | 为探讨阿霉素心肌病的发病机理，采用大鼠阿霉素心肌病模型，于实验第２，４，６周末，分别采血检测血清一氧化氮（ＮＯ），丙二醛含量，并于实验６周后对大鼠心肌进行病理形态学观察。结果：实验中不同时期所测ＡＤＲ组血清ＮＯ，ＭＤＡ值，均较正常对照组明显升高，且随观察时间的延长而增加，并与病理改变相一致。提示：ＡＤＲ可使大鼠诱生ＮＯ和促进氧自由基的释放，从而导致大鼠阿霉素心肌病。
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| 关 键 词： | 阿霉素 心肌病 一氧化氮 氧自由基 发病机理 |
EXPERIMENTAL RESEARCH ON MECHANISMS OF CARDIOMYOPATHYINDUCED BY ADRIAMYCIN IN RATS |
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| Zhao Jianmei,Jiang Xiaotian,Xu Meiyu.EXPERIMENTAL RESEARCH ON MECHANISMS OF CARDIOMYOPATHYINDUCED BY ADRIAMYCIN IN RATS[J].ACTA Academiae Medicinae Nantong,1999,19(2):160-161. |
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| Authors: | Zhao Jianmei Jiang Xiaotian Xu Meiyu |
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| Abstract: | The present study was undertaken to examine the mechanisms of cardiomyopathy induced by adriamycin (ADR) in rats.Serum content of nitric oxide (NO) and malondialdehyde (MDA) of model rats ( n]=10) were measured respectively after two-week,four-week and six-week experiment.Myocardial histopathological observation was performed after six-week experiment and compared with control group. Results: Serum content of NO and MDA increased gradually in ADR group,which were significantly higher than that in control group ( P <0.01) and identical to myocardial histopathological observations. Conclusions: ADR may make the rats induce NO,release Oxygen free radical and lead to cardiomyopathy. |
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| Keywords: | adriamycincardiomyopathynitric oxideoxygen free radical |
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