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大鼠损伤神经组织中睫状神经节营养因子的基因表达
引用本文:顾晓松,丁斐.大鼠损伤神经组织中睫状神经节营养因子的基因表达[J].南通医学院学报,1999,19(3):241-242.
作者姓名:顾晓松  丁斐
作者单位:南通医学院神经科学研究所
基金项目:国家杰出青年科学基金,江苏省教委青蓝工程资助
摘    要:探索大鼠损伤神经组织中CNTF基因表达,方法采用RT-PCR,半定量分析大鼠正常坐神经与坐骨神经横断损伤1周、2周、4周远侧端中CNTF的基因表达。结果在正常大鼠坐骨神经组织中,CNTF基因呈低表达。

关 键 词:坐骨神经损伤  RT-PCR  CNTF  基因表达

THE GENE EXPRESSION OF CILIARY NEUROTROPHIC FACTOR IN THE LESIONED NERVOUS TISSUE OF RAT
Gu Xiaosong,Ding Fei,Cao Zheng,Yao Dengbing,Ke Jing,Cui Xuezhi.THE GENE EXPRESSION OF CILIARY NEUROTROPHIC FACTOR IN THE LESIONED NERVOUS TISSUE OF RAT[J].ACTA Academiae Medicinae Nantong,1999,19(3):241-242.
Authors:Gu Xiaosong  Ding Fei  Cao Zheng  Yao Dengbing  Ke Jing  Cui Xuezhi
Abstract:Objective: To evaluate the gene expression of ciliary neurotrophic factor in the lesioned nervous tissue of rat. Methods: For semi-quantitative analysis, RT-PCR method were made in the detection of the levels of CNTF mRNA in the distal stumps at 1, 2, and 4 weeks following transection of sciatic nerve. Results: The level of CNTF mRNA was low in the normal sciatic nerve, and that was increased at 1, 2 and 4 weeks after sciatic nerve transection. Conclusions: The expression of CNTF mRNA was increased by the gene regulation in the distal stump following nerve lesion.
Keywords:Ciliary Neurotrophic factor(CNGF)sciatic nerveRT-PCRrat
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