| 大鼠损伤神经组织中睫状神经节营养因子的基因表达 |
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| 引用本文： | 顾晓松,丁斐.大鼠损伤神经组织中睫状神经节营养因子的基因表达[J].南通医学院学报,1999,19(3):241-242. |
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| 作者姓名： | 顾晓松 丁斐 |
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| 作者单位： | 南通医学院神经科学研究所 |
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| 基金项目： | 国家杰出青年科学基金,江苏省教委青蓝工程资助 |
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| 摘 要： | 探索大鼠损伤神经组织中ＣＮＴＦ基因表达，方法采用ＲＴ－ＰＣＲ，半定量分析大鼠正常坐神经与坐骨神经横断损伤１周、２周、４周远侧端中ＣＮＴＦ的基因表达。结果在正常大鼠坐骨神经组织中，ＣＮＴＦ基因呈低表达。
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| 关 键 词： | 坐骨神经损伤 RT－PCR CNTF 基因表达 |
THE GENE EXPRESSION OF CILIARY NEUROTROPHIC FACTOR IN THE LESIONED NERVOUS
TISSUE OF RAT |
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| Gu Xiaosong,Ding Fei,Cao Zheng,Yao Dengbing,Ke Jing,Cui Xuezhi.THE GENE EXPRESSION OF CILIARY NEUROTROPHIC FACTOR IN THE LESIONED NERVOUS
TISSUE OF RAT[J].ACTA Academiae Medicinae Nantong,1999,19(3):241-242. |
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| Authors: | Gu Xiaosong Ding Fei Cao Zheng Yao Dengbing Ke Jing Cui Xuezhi |
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| Abstract: | Objective: To
evaluate the gene expression of ciliary neurotrophic factor in the lesioned nervous tissue of rat.
Methods: For semi-quantitative analysis, RT-PCR method were made in the detection of the
levels of CNTF mRNA in the distal stumps at 1, 2, and 4 weeks following transection of sciatic
nerve. Results: The level of CNTF mRNA was low in the normal sciatic nerve, and that was
increased at 1, 2 and 4 weeks after sciatic nerve transection. Conclusions: The expression of
CNTF mRNA was increased by the gene regulation in the distal stump following nerve lesion. |
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| Keywords: | Ciliary Neurotrophic factor(CNGF)sciatic nerveRT-PCRrat |
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