Dynorphin A-(1–13) attenuates basal forebrain-lesion-induced amnesia in rats |
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Authors: | Makoto Ukai Tetsuya Kobayashi Tsutomu Kameyama |
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Abstract: | The effects of dynorphin A-(1–13), an endogenous κ opioid agonist, on basal forebrain (BF)-lesion-induced amnesia in rats were investigated using step-through-type passive avoidance task. The BF was lesioned by injecting the cholinergic neurotoxin ibotenic acid (6 μg/side). The number of rats achieving the cut-off time (600 s) of step-through latency (STL) in BF-lesioned group significantly decreased as compared with that in sham-operated group. Dynorphin A-(1–13) (0.3 μg) significantly increased the number of rats achieving the cut-off time of STL in BF-lesioned rats. These results suggest that dynorphins play an improving role in the impairment of memory processes in BF-lesioned rats. |
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Keywords: | Dynorphin A-(1– 13) Basal forebrain lesion Memory Rat |
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