注射用还原型谷胱甘肽钠与4种注射液的配伍稳定性考察

目的:考察注射用还原型谷胱甘肽钠与4种注射液的配伍稳定性。方法:注射用还原型谷胱甘肽钠分别与5%葡萄糖注射液、10%葡萄糖注射液、葡萄糖氯化钠注射液、0.9%氯化钠注射液配伍,各于25、37℃恒温浴中放置0、0.5、1.0、1.5、2.5、3h后考察配伍液的外观、pH值、吸收度、含量及不溶性微粒的变化。结果:注射用还原型谷胱甘肽钠与4种注射液配伍后,外观、pH值无明显变化;含量、不溶性微粒则存在着不同程度的变化。结论:在25、37℃的温度下,注射用还原型谷胱甘肽钠与4种注射液配伍后,应在2h内使用。

Stability of Reduced Glutathione Sodium in Four Different Injections

OBJECTIVE： To investigate the stability of reduced glutathione sodium after mixing with glucose injection （5% or 10%）, glucose and sodium chloride injection or 0.9% sodium chloride injection. METHODS： After mixing of reduced glutathione sodium with glucose injection （5% and 10%）, glucose and sodium chloride injection, and 0.9% sodium chloride injection, respectively, the 4 mixtures at 0, 0.5, 1.0, 1.5, 2.5, 3 h after mixing which were stored respectively in 25℃ or 37℃ thermostatic bath were observed in respect of the changes in appearance, pH values, absorbability, contents and the insoluble particles. RESULTS： After mixing of reduced glutathione sodium with glucose injection （5% and 10%）, glucose and sodium chloride injection, and 0.9% sodium chloride injection, respectively, the appearance and pH values of the 4 mixtures showed no obvious change, but the contents and the insoluble particles of the 4 mixtures cxperienced changes of different degree. CONCLUSION： Reduced glutathione sodium is stable in glucose injection （5% or 10%）, glucose and sodium chloride injection or 0.9% sodium chloride injection within 2h after mixing.