我院402例药品不良反应报告分析

目的分析医院药品不良反应（ADR），发生的特点与一般规律，为临床合理用药提供参考。方法对医院2007年至2009年收集的402例ADR报告进行统计分析。结果402例ADR报告中，静脉滴注较其他给药途径更易引发ADR（336例，83．58％）；抗微生物药物引起的ADR最多（174例，43．28％），喹诺酮类是引发ADR的主要抗微生物药（70例，40．23％），以左氧氟沙星为首；中药及中药注射剂发生率18．91％（76例）；ADR表现以皮肤及附件损害（134例，33．33％）、胃肠道反应（119例，29．60％）最常见。结论应慎用注射剂，合理使用抗微生物药，以减少ADR的发生。

Analysis on 402 Cases of ADR Reports in Our Hospital

Objective To analyze the features and general patterns of adverse drug reactions （ADR） occurred in our hospital for providing reference to rational drug use in clinic. Methods 402 of ADR case reports collected from 2007 to 2009 in our hospital were analyzed statistically. Results ADR was more likely caused by intravenous drip （336 cases, 83.58% ）. Antimicrobial drug induced ADR had the highest proportion（174 cases, 43.28% ）. Quinolones were the leading antimicrobials causing ADR（70 cases, 40. 23% ）, of which, levofloxacin dominated the first place, followed by Chinese traditional medicines and their injections （76 cases, 18.91% ）. The main presentations of ADR were the damage of skin and its appendages and gastrointestinal reaction, which were 134 cases（33.33% ） and 119 cases（29.60% ） respectively. Conclusion Injections should be used with caution. Rational use of antimicrobial drugs should be emphasized to reduce the incidence of ADR.