| 冠脉宁对麻醉犬脑血流量及脑血管阻力的影响 |
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| 引用本文： | 谢湘林,曲绍春,李春阳,杨世杰,金辉. 冠脉宁对麻醉犬脑血流量及脑血管阻力的影响[J]. 吉林大学学报(医学版), 2001, 27(2): 137-139 |
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| 作者姓名： | 谢湘林 曲绍春 李春阳 杨世杰 金辉 |
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| 作者单位： | 1. 吉林大学基础医学院药理学教研室,
2. 吉林省计划生育研究所 |
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| 摘 要： | 目的 :了解冠脉宁 ( GMN)对麻醉犬脑血流量、脑血管阻力、血压、心电图及心率作用的影响。方法 :以犬为实验对象 ,结扎一侧颈外动脉及枕动脉 ,以电磁流量计测颈动脉血流量 ,用多道生理记录仪记录血压、心电图及心率的变化。结果 :冠脉宁 ( 0 .4和 1.0 g/kg)、步长脑心通胶囊 ( CBCHNXT,0 .64g/kg)均可明显增加麻醉犬的脑血流量 ( P<0 .0 5、P<0 .0 1、P<0 .0 5)及明显降低脑血管阻力( P<0 .0 5) ,但对麻醉犬的血压、心电图及心率均无明显影响。结论 :冠脉宁通过增加脑血流量和降低脑血管阻力 ,改善脑血液循环。
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| 关 键 词： | 犬 脑血流量 脑血管阻力 冠脉宁 |
| 文章编号： | 0253-3707(2001)02-0137-03 |
| 修稿时间： | 2000-04-12 |
Effects of Guanmaining on brain-blood flowing volume and cereb rovascular resistance in dogs |
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| XIE Xiang-lin,QU Shao-chun,LI Chun-yang,YANG Shi-jie. Effects of Guanmaining on brain-blood flowing volume and cereb rovascular resistance in dogs[J]. Journal of Jilin University: Med Ed, 2001, 27(2): 137-139 |
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| Authors: | XIE Xiang-lin QU Shao-chun LI Chun-yang YANG Shi-jie |
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| Abstract: | Objective:To study the influence of Guanmaining (GMN) on the brain-blood flowing volume,cerebrovascular resistance,blood pressure and electrocardiogram (ECG) in anaesthetic dogs.Methods:Using dogs as experimental objects,we ligated one side of carotis external artery and occipitalis artery.Electromagnetic flowmeter was used to measure the blood flowing volume of carotis artery;polygraph system was used to investigate the change of blood pressure,ECG and heart rate.Results:Both GMN (0.4 g/kg,1.0 g/kg) and Capsule Buchangnaoxintong (CBCHNXT) (0.64 g/kg) could apparently increased the brain-blood flowing volume and reduced the cerebrovascular resistance ( P <0 05) in anaesthetic dogs,but they had no apparent effects on blood pressure,ECG and heart rate.Conclusion:GMN has a certain improving effects on brain blood circulation by increasing the brain-blood flowing vlume and reducing the cerebrovascular resistance. [ |
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| Keywords: | dog brain-blood flowing volume brain vessel resistance Guanmaining |
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