吉西他滨联合5-FU与奈达铂方案时辰化疗晚期食管癌临床观察

目的探讨吉西他滨（GEM）联合5-氟尿嘧啶（5-Fu）与奈达铂（NDP）时辰化疗晚期食管癌的近期疗效及不良反应。方法 GEM2000 mg/m2分d1、8静脉点滴,5-Fu 2500 mg/m2分d1～5（15：00-18：00）微量泵静脉输注,奈达铂75 mg/m2分d1-3静脉点滴,于5-Fu前2 h应用亚叶酸钙200 mg/d,21 d为1个周期,2个周期后评价疗效。结果治疗周期中位值为4.5个周期,CR2例,PR14例,SD5例,PD5例,总有效率（CR＋PR）为61.5%（16/26）。主要不良反应是骨髓抑制和胃肠道反应。无Ⅳ度骨髓抑制,口腔炎、肝肾毒性等均较轻。结论吉西他滨（GEM）联合5-氟尿嘧啶（5-Fu）与奈达铂（NDP）时辰化疗晚期食管癌疗效确切,安全性好。

Gemcitabine plus 5-FU and nedaplatin chemotherapy for advanced esophageal hour program of clinical observation

Objective To explore the efficacy and adverse reactions of gemcitabine（GEM） combined with 5-fluorouracil（5-Fu） and nedaplatin（NDP） with advanced esophageal cancer chrono-chemotherapy.Methods GEM2000 mg /m2 ivdrip d1、8 intravenous,5-Fu 2500 mg/m2 divided d1 ～ 5（15： 00-18： 00） micro pump infusion,nedaplatin 75 mg/m2 d1-3 hours intravenously,at 2 hours before 5-Fu applied leucovorin 200 mg/d,21 d is a cycle,evaluated after 2 cycles.Results The median treatment cycle was 4.5 cycles,CR 2 cases,PR 14 cases,SD 5 cases,PD 5 cases,the total effective rate（CR ＋ PR） was 61.5%（16 /26）.The main adverse reaction was myelosuppression and gastrointestinal reactions.No Ⅳ myelosuppression,stomatitis,liver and kidney toxicity Dengjun light.Conclusion The gemcitabine（GEM） combined with 5-fluorouracil（5-Fu） and nedaplatin（NDP） with advanced esophageal cancer chrono-chemotherapy is effective and security.