血清降钙素原和超敏C-反应蛋白在AECOPD的作用

目的探讨血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平在AECOPD患者的治疗及预后判断的临床意义。方法选择48例AECOPD及46例COPD稳定期患者,分别测定其PCT、hs-CRP。同时行痰细菌培养。结果 AECOPD组的PCT、hs-CRP水平明显高于COPD稳定期组(P<0.05)。PCT水平与细菌感染有关,AECOPD组中细菌学培养阳性者PCT水平高于阴性者。AECOPD患者中PCT阳性组好转率70.37%,PCT阴性组好转率85.71%。结论在AECOPD患者中,PCT和hs-CRP是较好的诊断指标,尤其在细菌感染的判断上PCT较hs-CRP更有临床价值。PCT可提示病情的严重程度及预后情况。

Clinical significance of serum Procalcitonin and hs C-reactive protein levels on AECOPD

Objective To explore the clinical significance of serum procalcitonin(PCT),hs C-reactive protein(hs-CRP) level on diagnosis,treatment and prognosis of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) patients.Methods 48 patients with AECOPD and 46 patients with COPD in stable were selected,and then the PCT,hs-CRP were tested.At the same time,sputum bacterial cultures and lung function were made.Results hs-CRP and PCT levels in AECOPD group were significantly higher than those in COPD stable groups with statistical differences(P<0.05).PCT levels were positively related with bacterial infections,and in AECOPD group,PCT levels with positive sputum bacterial cultures were significantly higher than those with negative sputum bacterial cultures.In AECOPD group,improvement rate of PCT in positive ones was 70.37%,and 85.71% in negative ones.Conclusion In AECOPD patients,PCT and hs-CRP are good diagnostic index,especially in bacterial infections.PCT may indicate the severity of the illness and prognosis.