顺铂,5-FU联合香菇多糖心包腔灌注治疗恶性心包积液的疗效评价

目的观察顺铂、5-FU联合香菇多糖心包腔灌注治疗恶性心包积液的毒副反应和疗效。方法恶性心包积液患者40例,用一次性中心静脉导管行心包腔置管闭式引流心包腔积液,引流后腔内每次注入DDP 60 mg、5-FU 1000 mg、香菇多糖6mg治疗。结果 CR 33例(82.5%);PR 4例(10%);NC 3例(7.5%),总有效率92.5%。副作用主要是胸痛,恶心和呕吐。结论顺铂、5-FU联合香菇多糖治疗恶性心包积液的疗效显著,可明显改善患者的生活质量,毒副反应轻微,可耐受。

Therapeutic effect of intrapleural injection of Cisplatin, 5-FU combined Lentinan on malignant pericardial effusion

Objective To explore the toxicities and efficacy of intrapleural injection of Cisplatin,5-FU combined Lentinan in the treatment of malignant pericardial effusion.Methods Splanchnocoele close drainage with central venous catheter were performed in forty cases of malignant pericardial effusion and then DDP 60 mg,5-FU 1000 mg and Lentinan 6 mg were perfused.Results In the forty patients,CR accounted for 82.5 %(33/ 40),PR 10 %(4/40),NC 7.5%(3/40),and the total effective rate was 92.5%(37/40).The main side effects were chest pain,nausea and vomit.Conclusion The results suggest that intrapleural injection of DDP,5-FU and Lentinan may be effective and safe in treating malignant pericardial effusion.