慢性支气管炎、COPD及肺心病患者BNP、肺功能和血气变化的研究

目的探讨慢性支气管炎(慢支)、COPD、慢性肺源性心脏病(肺心病)患者不同时期BNP(B型钠尿肽)、肺功能、动脉血气的变化。方法慢支、COPD、肺心病患者均空腹抽静脉血检测BNP;另抽动脉血检测血气;并行肺功能检测。三组间对比,并与正常组对照。结果由慢支发展到COPD、肺心病时BNP逐渐升高(P<0.05);慢支、COPD及肺心病各组FEV1/FVC、MMEF逐渐降低(P均<0.05),动脉血氧分压(PaO2)、PH值逐渐降低,二氧化碳分压(PaCO2)逐渐增高(P均<0.05)。BNP与PaO2、PH呈显著负相关(r=-0.69,-0.58,P均<0.01),而与PaCO2呈正相关(r=0.55,P<0.01)。BNP与FEV1/FVC、MMEF均呈显著负相关,P均<0.01)。结论血浆BNP水平与血气分析及肺功能变化关系密切,血浆BNP水平可以作为判断COPD病情严重程度的一个指标。

Research of B-tyepe natriuretic Peptide, blood gas analysis,and Pulmonary Function in Patients with Chronic Bronchitis,Chronic Obstructive Pulmonary Disease and Pulmonary Heart Disease

Objective To explore the change of BNP(B-type natriuretic peptide),pulmonary function and blood gas analysis in patients with chronic bronchitis,chronic obstructive pulmonary disease and pulmonary heart disease.Methods Vein blood was pumped from the patients with chronic bronchitis,chronic obstructive pulmonary disease and pulmonary heart disease,then testing plama BNP and pulmonary function,and artery blood was pumped for bood gas analysis.A contrastive study was performed among two groups and control group.Results From chronic bronchitis to chronic obstructive pulmonary disease and pulmonary heart disease,BNP tended to increase(P<0.05).From chronic bronchitis to chronic obstructive pulmonary disease and pulmonary heart disease,FEV1/FVC,MMEF tended to decrease(both P<0.05),PaO2,PH tended to decrease,and PaCO2 tended to increase(allP<0.05).The BNP levels were negatively related with PaO2,PH(r=-0.69,-0.58,bothP<0.01),and positively related with PaCO2(r=0.55,P<0.01).The BNP levels were negatively correlated with FEV1/FVC,MMEF(r=-0.71,-0.68,bothP<0.01).Conclusion The BNP levels had significant correlation with the blood analysis and pulmonary function parameter.The BNP level may be an indicator in judging the prognosis of the COPD.