有肺癌家族史的非小细胞肺癌患者的临床病理特征及预后

目的分析有明确肺癌家族史(FHLC)的非小细胞肺癌(NSCLC)患者的临床病理特征及预后。方法对浦东新区陆家嘴社区卫生服务中心登记的NSCLC切除术后患者的临床病理特征及预后进行分析。结果在428例NSCLC患者中,51例有FHLC。手术患者中早期肺癌的比例在FHLC和非FHLC患者中均较高。FHLC组的肺癌更多的为早期肺癌(P=0.037),且病理类型多为腺癌(P=0.018)。FHLC患者的死亡危险比为0.775(95%CI:0.534-1.275,P=0.327)。结论有FHLC的NSCLC患者具有病理早期和腺癌为主的特点,但其死亡危险比并未减少。

Clinicopathological characteristics and prognosis of Non-small cell lung cancer patients with a family history of lung cancer

Objective To analyze clinicopathological characteristics and prognosis of patients in non-small cell lung cancer(NSCLC) with family history of lung cancer(FHLC).Methods The clinicopathological characteristics and prognosis of NSCLC patients with FHLC registered in community health center of Lujiazui in Pudong New Area,Shanghai from June 1991 to October 2011 were retrospectively studied.Univariate analyses of the factors were performed using unpaired two-tailed t tests or chi-square test between the groups of FHLC and non-FHLC.The Cox proportional hazard model was used to evaluate the hazard ratio of death.Results Of the 428 NSCLC patients,51(11.9%) had a FHLC.The frequency of lung cancer with early stage was high in both groups of FHLC and non-FHLC patients.Patients with FHLC had a significantly higher frequency of early pa thology stage and a dominance of adenocarcinoma.Moreover,patients with FHLC had a hazard ratio of death of 0.775(95% confidence interval: 0.534-1.275,P=0.327) compared with the non-FHLC patients.Conclusions NSCLC patients with FHLC had a significantly higher frequency of early pathological stages and a dominance of adenocarcinoma.However,they were not at a decreased hazard ratio of death.These findings confirm the importance of early detection of lung cancer and employment of less invasive therapeutic interventions.