CD44v6和hTERT基因在胃癌患者中的表达及临床意义

目的检测胃癌患者组织中CD44v6、hTERT基因的表达情况及与临床病理因素的关系。方法采用免疫组织化学染色的方法检测胃黏膜肠化生、异型增生及胃癌组织中CD44v6、hTERT蛋白表达情况,并结合患者的临床病理资料进行分析。结果胃黏膜肠化生、异型增生及胃癌组织中CD44v6、hTERT蛋白表达阳性率显著高于正常胃黏膜,差异有统计学意义(P<0.05)。CD44v6、hTERT的表达与胃癌的分化程度、肿瘤大小无关(P>0.05),而与肿瘤的浸润深度、淋巴结转移及TNM分期密切相关(P<0.05)。结论 CD44v6、hTERT过表达与胃癌发生发展及浸润转移有关。

Expression and clinical significance of CD44v6 and hTERT in gastric carcinoma

Objective To detect the expression of CIM4v6 and hTERT in gastric carcinoma and to explore the correlation between their expression and clinical pathological factors. Methods The expressions of CIM4v6 and hTERT in gastric mucous membrane intestinalisation tissue, atypical hyperplasia tissue and gastric cancer tissue were detected by immunohistochemistry. The detection results combined with clinical pathological data were analyzed. Results The positive expression rates of CD44v6 and hTERT in the three different tissues mentioned above were significantly higher than those of normal gastric mucous membrane （ P 〈 0.05 ）. The expressions of CD44v6 and hTERT were closely related to the depth of infiltration,lymph node metastasis and TNM staging of gastric cancer （ P 〈0.05 ） ,however,which were not correlated with the differentiation degree and size of the carcinoma. Conclusion The expressions of CD44v6 and hTERT are significantly related to the pathogenesis, development, infiltration and metastasis of gastric cancer.