| 足月新生儿脐血ghrelin水平与瘦素、生长激素水平关系研究 |
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| 引用本文： | 黄小艺,蔡威,刘志伟,徐茵.足月新生儿脐血ghrelin水平与瘦素、生长激素水平关系研究[J].临床儿科杂志,2009,27(6). |
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| 作者姓名： | 黄小艺 蔡威 刘志伟 徐茵 |
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| 作者单位： | 1. 上海交通大学附属国际和平妇幼保健院新生儿科,上海,200030
2. 上海交通大学医学院附属新华医院临床营养中心,上海市儿科医学研究所,上海,200092 |
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| 基金项目： | 国家科技攻关项目，上海市医学重点学科资助项目 |
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| 摘 要： | 目的 探讨ghrelin调节胎儿生长发育的可能的作用机制.方法 采用放射免疫法测定78例足月新生儿脐血ghrelin、瘦素、生长激素水平,分析脐血ghrelin、瘦素、生长激素水平与出生体重的关系及脐血ghrelin水平与瘦素、生长激素水平间的关系.结果 小于胎龄儿(SGA)、适于胎龄儿(AGA)、大于胎龄儿(LGA)三组间新生儿脐血ghrelin、瘦素水平差异均有统计学意义(P均<0.01).脐血ghrelin水平与出生体重呈负相关性(r=-0.339,P=0.002),脐血瘦素水平与出生体重呈正相关性(r=0.373,P=0.001),脐血ghrelin水平与瘦素无相关性(P=0.175).脐血生长激素水平与出生体重、脐血ghrelin水平均无相关性(P=0.267,0.059).结论 Ghrelin及瘦素共同调节胎儿生长发育的机制可能与出生后两者的调节机制有所区别,Ghrelin可能并非通过刺激生长激素分泌而发挥调节胎儿生长发育作用.
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| 关 键 词： | 脐血 瘦素 生长激素 |
The relationship between cord blood ghrelin and leptin / growth hormone in term neonates |
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| HUANG Xiao-yi,CAI Wei,LIU Zhi-wei,XU Yin.The relationship between cord blood ghrelin and leptin / growth hormone in term neonates[J].The Journal of Clinical Pediatrics,2009,27(6). |
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| Authors: | HUANG Xiao-yi CAI Wei LIU Zhi-wei XU Yin |
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| Institution: | 1.Department of Clinical Nutrition Center;Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine;Shanghai Institute for Pediatric Research;Shanghai 200092;China;2.Neonatology Department;International Peace Muternity and Child Health Hospital Affiliated to Shanghai Jiaotong University;Shanghai 200030;Shanghai |
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| Abstract: | Objective To explore the mechanisms of ghrelin in fetal growth. Methods Cord blood plasma concentrations of ghrelin, leptin, and growth hormone were measured in 78 term neonates at birth by RIA. The correlation between birth weight, ghrelin, leptin, and growth hormone, and the relationship among the three hormones were analyzed. Results Concentrations of ghrelin and leptin were significantly different in SGA, AGA, and LGA neonates (P < 0.01). Leptin levels were positively (r = 0.373, P = 0.001), while ghrel... |
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| Keywords: | ghrelin |
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