| 依布硒固体分散体的制备及体外溶出度研究 |
| |
| 引用本文： | 张煤,于源,刘金花,刘忠荣,李章万.依布硒固体分散体的制备及体外溶出度研究[J].华西药学杂志,2005,20(6):512-513. |
| |
| 作者姓名： | 张煤 于源 刘金花 刘忠荣 李章万 |
| |
| 作者单位： | 四川大学华西药学院,四川,成都,610041;四川大学化学系,四川,成都,610041;地奥集团,四川,成都,610041 |
| |
| 基金项目： | 张煤,女,正攻读药物分析专业的硕士学位. |
| |
| 摘 要： | 目的提高依布硒的体外溶出速率。方法以固体分散技术制备依布硒固体分散体,并测定其体外溶出度,采用差示扫描量热法(DSC)进行物相分析。结果DSC分析表明,依布硒是以非晶体状态存在,用水溶性载体普朗尼克制备的分散体体外溶出60min大于60%。结论制备依布硒固体分散体可以提高其体外溶出度。
|
| 关 键 词： | 依布硒 固体分散体 溶出度 差示扫描量热法 |
| 文章编号： | 1006-0103(2005)06-0512-02 |
| 收稿时间： | 2005-06 |
| 修稿时间： | 2005年6月1日 |
Preparation and dissolution of Ebselen solid dispersion |
| |
| ZHANG Mei,YU Yuan,LIU Jin-hua,LIU Zhong-rong,LI Zhang-wan.Preparation and dissolution of Ebselen solid dispersion[J].West China Journal of Pharmaceutical Sciences,2005,20(6):512-513. |
| |
| Authors: | ZHANG Mei YU Yuan LIU Jin-hua LIU Zhong-rong LI Zhang-wan |
| |
| Institution: | 1. West China School of Pharmacy, Sichuan University, Chengdu 610041, China;2. Department of Chemistry, Sichuan University, Chengdu 610041, China;3. Diao Group, Chengdu 610041, China |
| |
| Abstract: | OBJECTIVE To improve the dissolution of ebselen in vitro.METHODS Ebselen solid dispersion was prepared. The dissolutions of the solid dispersion were detected. Differential scanning calorimetry(DSC) was used to determine the nature of the studied forms.RESULTS The DSC analysis suggested that ebselen was present in an amorphorous form in the solid dispersion.Ebselen solid dispersion was prepared with water-soluble carriers pluronic, released 60% in 60 min.CONCLUSION Ebselen solid dispersion can increase the solubility of ebselen in vitro. |
| |
| Keywords: | Ebselen Solid dispersion Dissolution DSC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
