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Postexposure Treatment of Marburg Virus Infection |
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| Authors: | Thomas W Geisbert Lisa E Hensley Joan B Geisbert Anders Leung Joshua C Johnson Allen Grolla Heinz Feldmann |
| Institution: | Author affiliations: National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, USA (T.W. Geisbert, J.B. Geisbert);;US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA (L.E. Hensley, J.C. Johnson);;Public Health Agency of Canada, Winnipeg, Manitoba, Canada (A. Leung, A. Grolla);;National Institutes of Health, Hamilton, Montana, USA (H. Feldmann) |
| Abstract: | Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus–based vaccine is administered 20–30 min after infection with Marburg virus. We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection. |
| Keywords: | Marburg virus filovirus vesicular stomatitis virus vaccine treatment viruses dispatch |