Reduced levofloxacin susceptibility in clinical respiratory isolates of Haemophilus influenzae is not yet associated with mutations in the DNA gyrase and topoisomerase II genes in Korea |
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| Authors: | Kim In-Suk Lee Nam Yong Kim Sunjoo Ki Chang-Seok Kim Sun-Hee |
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| Affiliation: | 1Department of Laboratory Medicine, Gyeongsang National University College of Medicine, Jinju, Korea.;2Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
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| Abstract: | Among 155 clinical respiratory isolates of Haemophilus influenzae in Korea, 6 (3.9%) isolates had reduced levofloxacin susceptibility (MICs ≥ 0.5 μg/mL). These six isolates had no significant quinolone resistance-determining region (QRDR) mutations in gyrA, gyrB, parC, or parE. This phenomenon suggests that neither evolution nor spread of any significant QRDRs mutations in clinical isolates occurred in Korea. Therefore, continued surveillance is necessary to observe the evolution of antibiotic-resistance and take measures to avoid the spread of drug-resistant clones. |
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| Keywords: | Haemophilus influenzae levofloxacin quinolone drug resistance DNA gyrase DNA topoisomerases Type II |
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