Evaluation of a cumulative SUV-volume histogram method for parameterizing heterogeneous intratumoural FDG uptake in non-small cell lung cancer PET studies |
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| Authors: | Floris H. P. van Velden Patsuree Cheebsumon Maqsood Yaqub Egbert F. Smit Otto S. Hoekstra Adriaan A. Lammertsma Ronald Boellaard |
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| Affiliation: | (1) Department of Nuclear Medicine & PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands;(2) Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands |
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| Abstract: | Purpose Standardized uptake values (SUV) are commonly used for quantification of whole-body [18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) studies. Changes in SUV following therapy, however, only provide a proper measure of response in case of homogeneous FDG uptake in the tumour. The purpose of this study was therefore to implement and characterize a method that enables quantification of heterogeneity in tumour FDG uptake. |
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