<Emphasis Type="Italic">IL17A</Emphasis> genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis |
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| Authors: | Taka-aki Nakada James A Russell John H Boyd Keith R Walley |
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| Institution: | (1) Critical Care Research Laboratories, Heart + Lung Institute, St. Paul’s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada |
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| Abstract: | Introduction Interleukin 17A (IL17A) plays a key role in host defense against microbial infection including Gram-positive bacteria. Genetic factors contribute
to the host defense, but the role of IL17A single nucleotide polymorphisms (SNPs) has not yet been investigated in severe sepsis. Therefore, we hypothesized that SNPs
in the IL17A gene alter susceptibility to infection and clinical outcome of severe sepsis. |
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