Vascular studies with histamine in vitro |
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| Authors: | D A A Owen Carol A Harvey E H Quinn |
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| Institution: | (1) Department of Pharmacology, The Research Institute, Smith Kline and French Research Ltd, Welwyn Garden City, Herts, UK |
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| Abstract: | In vitro studies to analyse the pharmacology of histamine-induced dilatation of resistance vessels in rat hindquarters have been made. Histamine caused dose-dependent dilatation of resistance vessels over the concentration range 10–9 to 10–6 mol. Responses to histamine were antagonized by cimetidine but not by mepyramine. Dimaprit also caused vasodilatation. Responses to dimaprit were inhibited by cimetidine 10–6 to 10–5
M. A pA2 of 6.43 (6.11–6.75, 95% confidence limits) was calculated for cimetidine in the resistance vessels of the hindquarters. |
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