MRI visualization of rodent liver structure and peritoneal adhesion with dialyzate enhancement. |
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Authors: | Jerry S Cheung Hong Guo Joseph C K Leung Kwan Man Kar N Lai Ed X Wu |
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Institution: | Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong. |
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Abstract: | This study investigated the use of peritoneal dialysis fluid (dialyzate) as a MR contrast agent to visualize the liver structure and peritoneal adhesion in rats at 7 T. Intraperitoneal injection of dialyzate (approximately 0.1 ml/g) yielded excellent and consistent intraperitoneal enhancement that delineated the liver lobular structure in all rats studied (N = 8). It also allowed the MR detection of peritoneal adhesions that were surgically induced. MR measurements of adhesion surface areas correlated well with the postmortem estimations (R = 0.99; N = 6). Dialyzate persisted in the intraperitoneal cavity for up to 2 days. T(1) and T(2) values of undiluted dialyzate were found to be 3017.5 +/- 35.3 ms and 108.4 +/- 2.0 ms, respectively. These findings demonstrated dialyzate-enhanced MRI as a potentially valuable technique to localize certain activities within liver (such as local tumor metastasis), and to monitor therapeutic interventions (e.g., against peritoneal adhesion) in preclinical research using small animal models. |
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Keywords: | peritoneal dialysis fluid dialyzate MRI intraperitoneal enhancement rodent liver peritoneal adhesion |
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