Total Mesorectal Excision for Rectal Cancer: Difference in Outcome for Low and High Rectal Cancer |
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Authors: | Arne E. Faerden M.D. Nazir Naimy M.D. Pål Wiik M.D. Ph.D. Ola Reiertsen M.D. Ph.D. Seyoum Weyessa M.D. Sigurd Trønnes M.D. Solveig Norheim Andersen M.D. Ph.D. Arne Bakka M.D. Ph.D. |
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Affiliation: | 1. Department of Surgery, Akershus University Hospital, L?renskog, Norway 2. Department of Pathology, Akershus University Hospital, L?renskog, Norway
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Abstract: | PURPOSE This prospective study was designed to assess the outcome through the first five years after the introduction of total mesorectal excision in 1993 in a Norwegian central hospital, with special regard to the difference between low (≤6 cm from anal verge) and high (>6 cm) rectal cancers. METHODS A total of 140 patients (81 males; median age, 64 (range, 29–87) years) underwent surgery for rectal cancer under curative intention. RESULTS Local recurrence rates were 8 of 44 (18 percent) for the low cancers and 5 of 96 (5 percent) for the high, a statistically significant difference (P = 0.0014). Corresponding numbers when the R1 resections are excluded were 5 of 36 (13 percent) for the low and 4 of 92 (4 percent) for the high cancers (P = 0.002). The five-year survival after R0 resections of cancers <6 cm was significantly reduced compared with those >6 cm. The five-year overall survival for the whole material was 72 percent. CONCLUSIONS Surgery alone for rectal cancer can achieve overall good results, with five-year overall survival of 72 percent. The prognosis of the cancers of the lower rectum seems to be inherently different from the tumors of the higher level, both concerning local recurrence and five-year survival, suggesting different biologic behavior of the two cancers. Presented at the meeting of the Norwegian Surgical Society, Oslo, Norway, October 18 to 22, 2004. |
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Keywords: | Rectal cancer Total mesorectal excision Lateral nodal spread Difference in survival between low and high rectal cancer Local recurrence Anastomotic leak |
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