Polymorphisms and haplotypes of the gene encoding the estrogen-metabolizing CYP19 gene in Korean women: no association with advanced-stage endometriosis |
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Authors: | Sung Eun Hur Sara Lee Ji Young Lee Hye-Sung Moon Hyung Lae Kim Hye Won Chung |
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Institution: | (1) Department of Obstetrics and Gynecology, Konyang University College of Medicine, Daejeon, South Korea;(2) Department of Obstetrics and Gynecology, Ewha Womans University Mokdong Hospital, 911-1 Yang-Cheon-Ku Mock-6-Dong, 158-710 Seoul, South Korea;(3) Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, South Korea;(4) Department of Biochemistry, Ewha Womans University School of Medicine, Seoul, South Korea |
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Abstract: | A variety of factors affect the development of endometriosis, including hormonal status and genetic factors. The growth of
endometriosis is stimulated by local estrogen production in conjunction with circulating estrogen. The CYP19 gene encodes
a steroid aromatase that catalyses the conversion of C-19 androgens to estrogens. This study investigated whether polymorphisms
of the CYP19 gene are associated with the risk of advanced endometriosis in Korean women. Blood samples were collected from
224 female patients with endometriosis of stages III and IV, as diagnosed by both pathologic and laparoscopic findings, and
from a control group comprising of 188 women undergoing laparoscopic surgery or laparotomy for nonmalignant lesions. Single-nucleotide
polymorphisms, restriction fragment length polymorphisms, and tetranucleotide tandem repeat polymorphisms were discriminated
by the polymerase chain reaction (PCR). Haplotype analysis was also performed. CYP19 115T>C, 240G>A, and 1531C>T polymorphisms
and TTTA]n tetranucleotide repeat polymorphisms in the CYP19 gene and their haplotypes were not significantly associated with the risk
of endometriosis. The risk of endometriosis also did not increase significantly with the number of higher risk alleles of
the CYP19 gene. In conclusion, our findings suggest that CYP19 genetic polymorphisms are not associated with advanced-stage
endometriosis in Korean women. |
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Keywords: | CYP19 gene polymorphism Haplotype Estrogen-metabolizing gene Advanced-stage endometriosis |
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