| 线粒体与心肌缺血/再灌注损伤 |
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| 引用本文： | 李雪丽,刘建勋. 线粒体与心肌缺血/再灌注损伤[J]. 中国药理学通报, 2012, 28(12): 1633-1636 |
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| 作者姓名： | 李雪丽 刘建勋 |
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| 作者单位： | 1. 中国中医科学院西苑医院实验研究中心,北京,100091;北京中医药大学,北京,100029
2. 中国中医科学院西苑医院实验研究中心,北京,100091 |
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| 基金项目： | 国家自然科学基金重点项目，重大新药创制综合性中药新药研究开发技术平台 |
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| 摘 要： | 心肌缺血/再灌注损伤会破坏线粒体稳态平衡引起功能紊乱,如线粒体ATP合成减少、ROS生成增加、Ca2+超载、膜通透性增加、线粒体片段化等,这些事件相互作用从多条途径参与I/R过程,是心肌I/R损伤的重要原因。对I/R中线粒体病理变化及I/R损伤线粒体保护途径的最新研究进展进行综述,为基于线粒体途径的心血管疾病药物防治研究提供参考。
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| 关 键 词： | 缺血/再灌注 线粒体膜通透性 线粒体形态 ROS Ca2+ mPTP mKATP |
Mitochondria and myocardial ischaemia/reperfusion injury |
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| LI Xue-li , LIU Jian-xun. Mitochondria and myocardial ischaemia/reperfusion injury[J]. Chinese Pharmacological Bulletin, 2012, 28(12): 1633-1636 |
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| Authors: | LI Xue-li LIU Jian-xun |
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| Affiliation: | 1(1.Experimental Research Center,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;2.Beijing University of Chinese Medicine,Beijing 100029,China) |
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| Abstract: | Myocardial ischaemia/reperfusion(I/R) cause a wide array of alterations of mitochondrial homeostasis,such as loss of ATP synthesis,increase of ROS generation,Ca2+overload,membrane permeabilization,fragmentation of mitochondria and so on.The series of events are linked together and involved in the process of I/R injury,play critical roles in cardiomyocytes injury.This paper reviews the advancement of mitochondrial pathological changes during I/R and mitochondrial protective pathway of I/R injury,in order to understand the important mechanisms of I/R injury associated with mitochondria and provide references for cardiovascular disease treatment strategies and drug development based on mitochondrial protection. |
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| Keywords: | ischaemia/reperfusion mitochondrial permeability mitochondrial morphology ROS Ca2+ mPTP mKATP |
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