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| 肠缺血再灌注对大鼠肺组织一氧化氮及一氧化氮合酶的影响 | |
| 引用本文： | 宇克莉,毕平,李会强,崔华雷.肠缺血再灌注对大鼠肺组织一氧化氮及一氧化氮合酶的影响[J].天津医科大学学报,2000,6(2):165-167. |
| 作者姓名： | 宇克莉 毕平 李会强 崔华雷 |
| 作者单位： | 1. 天津师范大学生物系 2. 天津医科大学医学检验系 3. 天津市儿童医院 |
| 摘 要： | 目的：观察大鼠肠缺血再灌注后肺泡巨噬细胞活化分泌ＮＯ及肺组织内ＮＯＳ的变化。方法：建立实验大鼠肠缺血再灌注模型，采用Ｇｒｉｅｓｓ法和分光光度法分别测定肺组织内ＮＯ及ＮＯＳ的活性。结果：肠血再灌注组肺泡巨噬细胞分泌ＮＯ的水平及肺内ＮＯＳ的水平均显著高于假手术对照组。结论：肠缺血再灌注后肺内巨噬细胞的ｉＮＯＳ被激活，大量合成并释放ＮＯ，其作用一方面可增强杀菌功能，另一方面导致肺组织损伤。 |
| 关 键 词： | 脑缺血再灌注 肺泡 巨噬细胞 一氧化氮合酶 |
| 文章编号： | 1006-8147(2000)02-0165-03 |
| 修稿时间： | 2000-02-21 |
Effect of the ischemia-reperfusions of small intestine on nitric oxide and nitric oxide synthase in lung tissue of rats |
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| YU Ke-li,BI Ping,LI Hui-qiang,CUI Hua-lei.Effect of the ischemia-reperfusions of small intestine on nitric oxide and nitric oxide synthase in lung tissue of rats[J].Journal of Tianjin Medical University,2000,6(2):165-167. | |
| Authors: | YU Ke-li BI Ping LI Hui-qiang CUI Hua-lei |
| Institution: | YU Ke-li ,BI Ping ,LI Hui-qiang ,CUI Hua-lei ;(Biology Department , Tianjin Normal University 300074) |
| Abstract: | Objective:The purpose of this study was to evaluate the level of nitric oxide (NO) secreted by alveolar phagocyte and the activity of nitric oxide synthase (NOS) in lung tissue after the ischemia reperfusions in rat's small intestine Methods:Ischemia reperfusions models of rat's small intestine were set up The NO level and NOS activity in lung tissue were respectively measured by Griess method and spectrophotometry Results:The results showed that comparing with the control group, the level of NO and activity of NOS were obviously enhanced in mould group Conclusion:After the ischemia reperfusions in rat's small intestine, the induced nitric oxide synthase (iNOS) were activated in alveolar phagocyte, plenty of NO were synthesized and released , which caused bactericidal power enhanced and the lung tissue damaged |
| Keywords: | ischemia-reperfusions alveolar phagocyte nitric oxide nitric oxide synthase |
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