Bactericidal activity of ceftobiprole combined with different antibiotics against selected Gram-positive isolates |
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Authors: | F Campanile D Bongiorno G Mongelli G Zanghì S Stefani |
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Institution: | 2. Department of Surgery, Policlinico Vittorio Emanuele University Hospital - General Surgery and Oncology Unit, University of Catania, Italy |
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Abstract: | This study investigated the in vitro susceptibility of ceftobiprole and its potential synergistic activity in combination with other antimicrobials against 46 selected Gram-positive pathogens displaying resistance or decrease susceptibility to several drugs. The gradient-cross method was used to assess synergism between ceftobiprole and daptomycin, levofloxacin, linezolid, rifampicin and piperacillin/tazobactam. Time-kill curves were performed for seven representative isolates. Ceftobiprole MICs ranged from 0.25–6?mg/L for staphylococci; 4–≥32?mg/L for Enterococcus faecalis, and 0.38–≥32?mg/L for E. faecium. Ceftobiprole plus daptomycin was synergistic against all isolates. Ceftobiprole plus linezolid was synergistic against 4 isolates belonging to different species. Ceftobiprole plus levofloxacin was synergistic only against enterococci. In conclusion, ceftobiprole exhibited a potent in vitro antibacterial activity and exhibited synergy with daptomycin against all Gram-positive isolates, despite their antibiotic resistance phenotypes. The use of ceftobiprole in combination may provide a promising alternative therapy for the treatment of resistant Gram-positive infections. |
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Keywords: | Ceftobiprole Combinations Gram-positive Time-kill curves |
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