通心络促血管生成作用的实验研究

目的　探讨中药通心络对鸡胚绒毛尿囊膜 (CAM)模型血管生成作用的影响。方法　运用血清药理学的方法制备药物血清 ,鸡胚随机分为空白血清组、贝复济组及通心络大、小剂量组 ,检测尿囊膜的血管增生程度。结果　通心络大剂量组CAM的血管增生数明显高于空白血清组 (P <0 .0 5) ,而与贝复济组无明显差异 (P >0 .0 5) ;通心络小剂量组与空白血清组相比无明显差异 (P >0 .0 5)。结论　通心络可促进鸡胚绒毛尿囊膜的血管增生 ,具有一定的促血管新生作用

The experiment reserch of angiogenes effect of Tongxinluo capsule on the chick embryo chorioallantoic membrane model

Objective To study the stimulate angiogenes effect of Tongxinluo capsule on the chick embryo chorioallantoic membrane (CAM) model.Methods 32 chick embryo (CE) were randomly divided into 4 groups,8 CE in group A were treated with vacuity blood serum as negative controls,8 CE in group B were treated with basic Fibroblast Growth Facter as positive controls,8 CE in group C and 8 CE in group D were treated with maxiums and micro dose of Tongxinluo herbal serum respectively.After 3 days of incubated,count the first and second grade vessels.Results The proliferation of vessels in group C was obviously increase than that in group A (P<0.05) and almost equaled to that of group B (P>0.05),but group D has no obviously difference compared with group A (P> 0.05 ).Conclusion Tongxinluo capsule can stimulate angiogenesis of the Chick embryo CAM model.