急性缺血性心肌损伤患者肌钙蛋白T检测的临床意义

目的 :为了早期、准确地判定急性缺血性心肌损伤程度。方法 :采用酶联免疫吸附方法 ,对 41例急性心肌梗塞患者、 38例心绞痛 (AP)疑有微小心肌损伤 (MMD)患者以及 40例健康 (HP)人进行心脏肌钙蛋白 T(c Tn T)测定 ,同时与 CK和CK— MB两项酶学指标相比较。结果 :AMI组 ,c Tn T、CK及 CK— MB三者之间的异常率无明显差别 (异常率 97%～ 10 0 % ) ;而AP组 ,c Tn T的异常率为 44 .7% ,明显高于 CK异常率的 7.9%和 CK— MB异常率的 13.2 %。与健康组相比 ,AP组的 c Tn T测定的水平明显高于对照组水平 (P<0 .0 1)。结论 :对于不同程度的急性缺血性心肌损伤的诊断 ,c Tn T较 CK及 CK— MB,具有更高的灵敏度及特异性。

Detection cardiac troponin T of acute ischaemic myocar dial damage:clinical significance

Objective To judge the degree of acute ischaemic myocardial damage early and exactly.Method Cardiac tropnin T of 41 patients with AMI and 38 patients with uncertain minor myocardial damage angina and 40 control subjects was detected by ELISA,compared with CK and CK-MB altogether.Results There was no significant difference in cTnT,CK and CK-MB of AMI patients(abnormal rate between 97%～100%),but for the angina patients,abnormal rate of cTnT(44.7%)was much higher than that of CK (7.9%)and CK-MB(13.2%);and cTnT levels of angina patients was much higher than that of control subjects(P<0 01).Conclusion It is suggested that cTnT is much higher sensitivity and specificity than CK and CK-MB for the diagnosis of acute ischaemic myocar dial damage.