Toremifene resistance in a rat mammary tumour model. |
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| Authors: | J A Kellen E Georges V Ling M Dubsky |
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| Affiliation: | Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada. |
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| Abstract: | The effect of Toremifene on cell growth in vitro was tested on the R3230AC rat mammary adenocarcinoma as model. Toremifene differed from Tamoxifen in that it did not induce resistance; some cross-resistance was observed in Tamoxifen tolerant tumour cell lines. Toremifene does not influence P-glycoprotein expression in this model and at the levels studied. |
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