不同方法注射乙肝免疫球蛋白阻断HBV宫内传播的研究

目的：研究不同方法注射乙型肝炎免疫球蛋白（HBIG）对HBsAg和HBeAg双阳性孕妇的乙肝病毒（HBV）宫内阻断作用。方法：A组32例，孕16周起肌注HBIG，每4周1次至分娩；B组32例。孕28周起肌注HBIG，每4周1次至分娩；C组31例未予用药。结果：A组和B组孕妇HBVDNA水平C组显著下降（P〈0．05），其新生儿宫内感染率明显低于C组（分别为5.88％和15.62％），P〈0．05。3组孕妇及其新生儿未发现有不良反应。结论：HBkAg和HBeAg双阳性孕妇孕中期多次注射HBIG可有效减少HBV宫内感染发生率。

CLINICAL STUDY ON INTERRUPTION OF HBV TRANSMISSION IN UTERUS BY DIFFERENT METHODS OF MUTIPLE HBV SPECIFIC IMMUGLOBULIN INJECTION FOR HBSAG POSITIVE PREGNANT WOMEN

Objective:To study the interruption effect of different method of HBV specific immunoglobulin(HBIG) injection for both HBsAg and HBeAg pregnant women.Methods:Group A(32 cases)received 200IU of HBIG intramuscalaly every 4 week before delivery since the 16th week of gestation.Group B(32 cases)received 200IU of HBIG intramuscalaly every 4 week before delivery since the 28th week of gestation.Group C(31 cases)were followed up without any treatment.Results:HBV DNA in the A and B groups decreased obviously(P<0.05)and the rates of intrauterine infection in the A and B groups was significantly lower than that of C group.(5.88% and 15.62%,P<0.05).No side effects were found in the pregnant women and their neonates in the 3 groups.Conclusion:The rate of HBV intrauterine infection in both HBsAg and HBeAg pregnant women can be decreased by injecting mutiple HBV specific immunglobulin in the medial gregnancy.