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Cathepsin B inhibition interferes with metastatic potential of human melanoma: an <Emphasis Type="Italic">in vitro</Emphasis> and <Emphasis Type="Italic">in vivo</Emphasis> study |
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| Authors: | Paola Matarrese Barbara Ascione Laura Ciarlo Rosa Vona Carlo Leonetti Marco Scarsella Anna M Mileo Caterina Catricalà Marco G Paggi Walter Malorni |
| Institution: | 1.Department of Therapeutic Research and Medicines Evaluation,Istituto Superiore di Sanità,Rome,Italy;2.Department of Experimental Chemotherapy,Regina Elena Cancer Institute,Rome,Italy;3.Development of Therapeutic Programs,Regina Elena Cancer Institute,Rome,Italy;4.Department of Dermatology-Oncology,S. Gallicano Dermatological Institute,Rome,Italy |
| Abstract: | BackgroundCathepsins represent a group of proteases involved in determining the metastatic potential of cancer cells. Among these are cysteinyl- (e.g. cathepsin B and cathepsin L) and aspartyl-proteases (e.g. cathepsin D), normally present inside the lysosomes as inactive proenzymes. Once released in the extracellular space, cathepsins contribute to metastatic potential by facilitating cell migration and invasiveness. |
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