Absence of IFNγ expression induces neuronal degeneration in the spinal cord of adult mice |
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Authors: | Sheila CS Victório Leif A Havton Alexandre LR Oliveira |
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Institution: | 1.Department of Anatomy, Cell Biology, Physiology and Biophysics,Institute of Biology, University of Campinas (UNICAMP),Campinas,Brazil;2.Department of Neurology,University of California,Los Angeles,USA |
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Abstract: | Background Interferon gamma (IFNγ) is a pro-inflammatory cytokine, which may be up-regulated after trauma to the peripheral or central
nervous system. Such changes include reactive gliosis and synaptic plasticity that are considered important responses to the
proper regenerative response after injury. Also, IFNγ is involved in the upregulation of the major histocompatibility complex
class I (MHC class I), which has recently been shown to play an important role in the synaptic plasticity process following
axotomy. There is also evidence that IFNγ may interfere in the differentiation and survival of neuronal cells. However, little
is known about the effects of IFNγ absence on spinal cord neurons after injury. |
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Keywords: | |
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