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Spectrophotometric determination of <Emphasis Type="Italic">p</Emphasis>-aminophenol in drugs using 5,7-dichloro-4,6-dinitrobenzofuroxan reagent in micellar medium
Authors:R F Bakeeva  T S Gorbunova  O E Vakhitova  A I Gaisina  L M Yusupova  S Yu Garmonov  V F Sopin
Institution:(1) Kazan State Technological University, Kazan, Tatarstan, Russia;
Abstract:A new spectrophotometric method for determining p-aminophenol in micellar aqueous dimethylsulfoxide (DMSO) media with non-ionogenic surfactant Triton X-100 that makes use of 5,7-dichloro-4,6-dinitrobenzofuroxan as an indicator has been developed. Using the proposed method, it is possible to detect an admixture of p-aminophenol in paracetamol (acetaminophen) in such media on a level that is much lower than the limiting concentration. The presence of Triton X-100 in the form of micelles improves the sensitivity of spectrophotometric determination compared to that of standard techniques.
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