2型糖尿病患者周围血管病变的踝肱指数检测与相关因素分析

目的探讨2型糖尿病患者周围血管病变(PAD)的相关影响因素,为早期筛查提供临床参考。方法选取2014年9月-2015年2月在我院住院的2型糖尿病患者189例,采用超声多普勒血流探测仪进行下肢血管病变的踝肱指数(ABI)测定,排除掉ABI≥1.3(提示动脉钙化)患者16例,余下分为PAD组(ABI0.9)和非PAD组(0.9≤ABI1.3)。回顾性分析两组患者的临床资料、糖尿病并发症及降糖方案等情况,对可能发生糖尿病周围血管病变的相关因素进行Logistic多元回归分析。结果有26例患者发生周围血管病变,发病率为13.8%。Logistic多元回归分析提示:年龄、病程及低密度脂蛋白是糖尿病周围血管病变的独立危险因素(P0.05)。结论 2型糖尿病患者有较高的PAD患病率,医务人员应做好早期筛查工作,教育和指导糖尿病患者加强血脂及血压控制。

Detection of ankle-brachial index and related factors analysis for peripherals arterial disease for patients with type 2 diabetes

Abstract Objective To study the related risk factors for peripherals arterial disease(PAD)for patients with type 2 diabetes,and to provide clinical reference for early screening.Method 189 patients with type 2 diabetes were en-rolled in our hospital from September 2014 to February 2015.The ankle brachial index(ABI)of lower extremity vas-cular disease were measured by ultrasonic Doppler blood flood flow detector.16 patients with high ABI ! 1.3(Hint of arterial calcification)were excluded,then they were divided into two groups according to the values of ABI,PAD group with ABI<0.9 and non-PAD group with 0.9≤ABI<1.3.Clinical data,complications,the treatment plan and drug combination were analyzed retrospectively,single factor and multi-factor Logistic regression analysis were per-formed to analyze the risk factors for PAD for patients with type 2 diabetes.Results Among the 189 type 2 diabetic patients,26(13.8%)were diagnosed as PAD.Age,course of disease,TG,LDL-C,blood pressure,24 h microalbumin-uria,the morbidity of hypertension,diabetic nephropathy,cerebrovascular disease and application of hypertension medication were significant difference between the two groups (P < 0.05).Results factors that were entered the model included age,course of disease,LDL-C,DBP and the morbidity of hypertension (P < 0.05).Conclusion Age, course of disease,LDL-C,DBP and the morbidity of hypertension was the independent risk factors for PAD,diabetes patients,especially those with advanced age and long course of disease should enhance controlling of blood lipid and blood pressure.