E Rosette Formation by Human T Lymphocytes: A Spontaneous Cell Mediated Cytotoxic Phencmenon |
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| Authors: | L. A. Fernandez R. Rajaraman J. M. Macsween |
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| Affiliation: | a Departments of Medicine and Microbiology, Dalhousie University, Camp Hill Hospital, Halifax, Nova Scotia, Canada |
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| Abstract: | The nature and significance of spontaneous association between unsensitized human T lymphocytes and sheep erythrocytes has Seen studied in relation to a possible cytotoxic reaction. Human lymphocytes and 51Cr labelled sheep erythrocytes when mixed in ratios of 5 or 10:l released 70-100% of 51Cr into the supernatants. This suggests that E rosette formation may be the first step in a spontaneous T cell mediated cytotoxic reaction to sheep erythrocytes. |
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