| 响应面法优化秦皮产地加工与饮片炮制一体化工艺研究 |
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| 引用本文： | 赵重博,王晶,吴建华,邹俊波,李晓尧,史亚军,王昌利.响应面法优化秦皮产地加工与饮片炮制一体化工艺研究[J].中草药,2018,49(20):4753-4759. |
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| 作者姓名： | 赵重博 王晶 吴建华 邹俊波 李晓尧 史亚军 王昌利 |
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| 作者单位： | 陕西中医药大学药学院 |
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| 基金项目： | 国家中医药管理局中医药行业科研专项（201507002） |
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| 摘 要： | 目的应用星点设计-响应面法优化秦皮产地加工与饮片炮制一体化工艺。方法以HPLC法和紫外分光光度法测得秦皮中秦皮甲素、秦皮乙素、秦皮素、秦皮苷和总香豆素含量的总评归一值(Y)为评价指标,以切制规格(X_1)、干燥温度(X_2)和干燥时间(X_3)为考察对象,利用星点设计效应面法优化秦皮的产地加工与饮片一体化工艺;并研究一体化秦皮饮片的抗炎镇痛效果。结果最佳一体化工艺为秦皮药材去粗皮后,切6 mm厚的丝,75℃干燥3.25 h;该工艺生产的秦皮饮片可显著减少冰醋酸致小鼠的扭体反应次数,延长潜伏期,抑制角叉菜胶诱导的大鼠足肿胀反应,明显或部分缓解肿胀程度;一体化秦皮饮片比传统饮片镇痛作用更加明显,差异显著(P0.05)。结论响应面法优选秦皮产地加工一体化工艺简便易行,准确度较好,为其他皮类饮片生产提供参考,具有一定的推广应用价值。
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| 关 键 词： | 秦皮 炮制一体化 星点设计 香豆素 总评归一值 |
| 收稿时间： | 2018/2/9 0:00:00 |
Optimization of integrative technology of primary processing for Fraxini Cortex based on response surface methodology |
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| ZHAO Chong-bo,WANG Jing,WU Jian-hu,ZOU Jun-bo,LI Xiao-yao,SHI Ya-jun and WANG Chang-li.Optimization of integrative technology of primary processing for Fraxini Cortex based on response surface methodology[J].Chinese Traditional and Herbal Drugs,2018,49(20):4753-4759. |
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| Authors: | ZHAO Chong-bo WANG Jing WU Jian-hu ZOU Jun-bo LI Xiao-yao SHI Ya-jun and WANG Chang-li |
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| Institution: | Shaanxi University of Chinese Medicine, Xianyang 712046, China,Shaanxi University of Chinese Medicine, Xianyang 712046, China,Shaanxi University of Chinese Medicine, Xianyang 712046, China,Shaanxi University of Chinese Medicine, Xianyang 712046, China,Shaanxi University of Chinese Medicine, Xianyang 712046, China,Shaanxi University of Chinese Medicine, Xianyang 712046, China and Shaanxi University of Chinese Medicine, Xianyang 712046, China |
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| Abstract: | |
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| Keywords: | Fraxini Cortex processing integration central composite design coumarin overall desirability |
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