| 基于UPLC-Q-Exactive Orbitrap-MS分析宣木瓜饮片化学成分 |
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| 引用本文： | 盛节英,周洪雷,周倩,孙立立,蒋海强,张世明,郭凤雪,侯立静,张翠珊,董书红.基于UPLC-Q-Exactive Orbitrap-MS分析宣木瓜饮片化学成分[J].中草药,2018,49(20):4773-4779. |
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| 作者姓名： | 盛节英 周洪雷 周倩 孙立立 蒋海强 张世明 郭凤雪 侯立静 张翠珊 董书红 |
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| 作者单位： | 山东中医药大学;山东省中医药研究院 |
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| 基金项目： | 国家公益性行业科研专项：30种中药饮片产地加工与炮制生产一体化关键技术规范研究——宣木瓜（201507002-2）；山东省自然科学基金项目（ZR2015PH009） |
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| 摘 要： | 目的采用超高效液相色谱-四级杆-静电场轨道阱(UPLC-Q-Exactive Orbitrap-MS),对宣木瓜饮片的化学成分进行快速识别和鉴定。方法采用Halo C_(18)(100 mm×2.1 mm,2.7μm)色谱柱,0.05%甲酸水溶液(A)-0.05%甲酸的乙腈溶液(B)为流动相,梯度洗脱,体积流量0.3 m L/min,柱温40℃,正、负离子模式扫描。结果共鉴定出宣木瓜饮片中25种化学成分。包括游离氨基酸5种、有机酸类11种、糖苷类2种、黄酮3种和三萜4种。结论该法可准确、快速地对宣木瓜饮片中化学成分进行定性分析,为阐明宣木瓜药效物质基础和优选质量控制指标提供科学依据。
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| 关 键 词： | 宣木瓜 超高效液相色谱-四级杆-静电场轨道阱 氨基酸类 有机酸类 黄酮类 三萜类 |
| 收稿时间： | 2018/3/19 0:00:00 |
Analysis on chemical constituents of fruit of Chaenomeles speciosa by UPLC-Q-Exactive Orbitrap-MS |
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| SHENG Jie-ying,ZHOU Hong-lei,ZHOU Qian,SUN Li-li,JIANG Hai-qiang,ZHANG Shi-ming,GUO Feng-xue,HOU Li-jing,ZHANG Cui-shan and DONG Shu-hong.Analysis on chemical constituents of fruit of Chaenomeles speciosa by UPLC-Q-Exactive Orbitrap-MS[J].Chinese Traditional and Herbal Drugs,2018,49(20):4773-4779. |
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| Authors: | SHENG Jie-ying ZHOU Hong-lei ZHOU Qian SUN Li-li JIANG Hai-qiang ZHANG Shi-ming GUO Feng-xue HOU Li-jing ZHANG Cui-shan and DONG Shu-hong |
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| Institution: | Shandong University of Traditional Chinese Medicine, Jinan 250355, China,Shandong University of Traditional Chinese Medicine, Jinan 250355, China,Shandong Academy of Traditional Chinese Medicine, Jinan 250000, China,Shandong Academy of Traditional Chinese Medicine, Jinan 250000, China,Shandong University of Traditional Chinese Medicine, Jinan 250355, China,Shandong University of Traditional Chinese Medicine, Jinan 250355, China,Shandong University of Traditional Chinese Medicine, Jinan 250355, China,Shandong Academy of Traditional Chinese Medicine, Jinan 250000, China,Shandong University of Traditional Chinese Medicine, Jinan 250355, China and Shandong University of Traditional Chinese Medicine, Jinan 250355, China |
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| Abstract: | |
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| Keywords: | fruit of Chaenomeles speciasa UPLC-Q-Exactive Orbitrap-MS amino acids organic acids flavonoids triterpenes |
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