| 华泽兰根部化学成分研究 |
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| 引用本文： | 张清清,陈静文,马一婷,李小环,刘呈雄,郭志勇,邹坤.华泽兰根部化学成分研究[J].中草药,2018,49(20):4798-4802. |
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| 作者姓名： | 张清清 陈静文 马一婷 李小环 刘呈雄 郭志勇 邹坤 |
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| 作者单位： | 三峡大学生物与制药学院天然产物研究与利用湖北省重点实验室 |
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| 基金项目： | 国家自然科学基金青年科学基金项目（81803383）；湖北省教育厅科学技术研究项目（Q20181201） |
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| 摘 要： | 目的研究菊科泽兰属植物华泽兰Eupatorium chinense根部的化学成分。方法采用正相硅胶柱色谱、制备薄层色谱及制备型HPLC等方法分离纯化,利用NMR、MS等波谱学方法鉴定化合物结构。结果从华泽兰醋酸乙酯部位分离鉴定了19个化合物,鉴定为泽兰素(1)、1-2-(1-acetoxymethyl-vinyl)-6-hydroxy-benzofuran-5-yl]-ethanone(2)、6-hydroxy-3β-methoxytrematone(3)、euparone(4)、8-methoxy-9-hydroxythymol(5)、dehydroespeleton(6)、8-methoxy-9-hydroxythymol 3-Oangelate(7)、9-hydroxythymol(8)、4-hydroxycinnamic acid methyl ester(9)、对羟基苯甲醛(10)、8,9-dehydro-10-hydroxythymol(11)、邻苯二甲酸二异丁基酯(12)、邻苯二甲酸二正丁酯(13)、对香豆酸(14)、dihydrocoumarin(15)、methylcaffeate(16)、2,5-dimethylphenol(17)、1H-吲唑(18)、(Z)-3-(hydroxymethyl)-7-methylocta-2,6-dienly1 acetate(19)。结论首次对华泽兰根部的化学成分进行研究,其中化合物2、3、5～11为首次从华泽兰中分离得到,化合物6、9、12、14～19为首次从泽兰属中分离得到,化合物1～4为苯并呋喃类化合物,是泽兰属中的特征性成分。
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| 关 键 词： | 华泽兰 泽兰素 邻苯二甲酸二异丁基酯 对香豆酸 1H-吲唑 |
| 收稿时间： | 2018/4/4 0:00:00 |
Chemical constituents from roots of Eupatorium chinense |
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| ZHANG Qing-qing,CHEN Jing-wen,MA Yi-ting,LI Xiao-huan,LIU Cheng-xiong,GUO Zhi-yong and ZOU Kun.Chemical constituents from roots of Eupatorium chinense[J].Chinese Traditional and Herbal Drugs,2018,49(20):4798-4802. |
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| Authors: | ZHANG Qing-qing CHEN Jing-wen MA Yi-ting LI Xiao-huan LIU Cheng-xiong GUO Zhi-yong and ZOU Kun |
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| Institution: | Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, Three Gorges University, Yichang 443002, China,Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, Three Gorges University, Yichang 443002, China,Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, Three Gorges University, Yichang 443002, China,Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, Three Gorges University, Yichang 443002, China,Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, Three Gorges University, Yichang 443002, China,Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, Three Gorges University, Yichang 443002, China and Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, Three Gorges University, Yichang 443002, China |
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| Abstract: | |
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| Keywords: | Eupatorium chinense L euparin diisobutyl phthalate p-coumaric acid 1H-indazole |
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