| 焦栀子炒制过程中HPLC图谱变化与外观颜色的动态关联研究 |
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| 引用本文： | 张雪,李晓庆,王云,李玲云,戴业佳,王清浩,麻印莲,宋嬿,张玉莲,吕婷婷,张村. 焦栀子炒制过程中HPLC图谱变化与外观颜色的动态关联研究[J]. 中草药, 2018, 49(17): 4029-4037 |
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| 作者姓名： | 张雪 李晓庆 王云 李玲云 戴业佳 王清浩 麻印莲 宋嬿 张玉莲 吕婷婷 张村 |
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| 作者单位： | 中国中医科学院中药研究所;河南中医药大学药学院;安徽中医药大学药学院;上海上药华宇药业有限公司 |
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| 基金项目： | 国家自然科学基金项目（81473356,81873010,81173553）;国家“重大新药创制”科技重大专项（2014ZX09304307001）;国家中药标准化项目（ZYBZH-Y-SH-38）;中国中医科学院自主选题（ZXKT16001,ZZ2014053） |
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| 摘 要： | 目的分析与焦栀子炒制过程中颜色变化密切相关的化学成分。方法利用色彩分析仪对焦栀子炒制过程中的样品进行色度值测定,并利用HPLC整体图谱分析对焦栀子过程样品中共有成分进行指认和相对峰面积计算,同时利用多元统计学方法对焦栀子过程样品进行颜色与成分关联与判别分析。结果本实验共筛选出与焦栀子炒制过程中与总色值(E*ab)高度相关的8个成分,即羟异栀子苷、6″-香豆酰京尼平龙胆二糖苷、西红花苷-I、西红花苷-II及峰I6、I12、C1、C2,此8种成分含量随焦栀子炒制颜色加深呈下降趋势。且实验结果显示焦栀子炒制过程中鸡屎藤次苷甲酯、去乙酰车叶草苷酸甲酯、羟异栀子苷、西红花苷-II、西红花苷-I及峰C1、C2、C4、C6、C7为含量变化较显著的10个成分。结论羟异栀子苷、西红花苷-I和西红花苷-II是焦栀子炒制过程中与外观颜色变化高度相关且含量变化显著的成分,可作为焦栀子质量控制的潜在质量标志物。
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| 关 键 词： | 焦栀子 炒制 HPLC 质量标志物 颜色 色度值 多元统计分析 色彩分析仪 动态关联 羟异栀子苷 6" -香豆酰京尼平龙胆二糖苷 西红花苷-I 西红花苷-Ⅱ 鸡屎藤次苷甲酯 去乙酰车叶草苷酸甲酯 |
| 收稿时间： | 2018-03-20 |
Dynamic correlation between constituents detected by HPLC and colors of samples in stir-frying process of Gardeniae Fructus Praeparatus |
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| ZHANG Xue,LI Xiao-qing,WANG Yun,LI Ling-yun,DAI Ye-ji,WANG Qing-hao,MA Yin-lian,SONG Yan,ZHANG Yu-lian,LV Ting-ting and ZHANG Cun. Dynamic correlation between constituents detected by HPLC and colors of samples in stir-frying process of Gardeniae Fructus Praeparatus[J]. Chinese Traditional and Herbal Drugs, 2018, 49(17): 4029-4037 |
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| Authors: | ZHANG Xue LI Xiao-qing WANG Yun LI Ling-yun DAI Ye-ji WANG Qing-hao MA Yin-lian SONG Yan ZHANG Yu-lian LV Ting-ting ZHANG Cun |
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| Affiliation: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230000, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, China,Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China,SPH Huayu Chinese Herbs Co., Ltd., Shanghai 200002, China,SPH Huayu Chinese Herbs Co., Ltd., Shanghai 200002, China,SPH Huayu Chinese Herbs Co., Ltd., Shanghai 200002, China and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, China;College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230000, China |
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