| 膜翅目昆虫提取物Ento-Ⅱ涂膜剂的镇痛及活血化瘀作用研究 |
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| 引用本文： | 张枝雪,黄茜,李玥,杨志斌,何亚楠,巫秀美,赵海荣.膜翅目昆虫提取物Ento-Ⅱ涂膜剂的镇痛及活血化瘀作用研究[J].中草药,2018,49(9):2108-2113. |
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| 作者姓名： | 张枝雪 黄茜 李玥 杨志斌 何亚楠 巫秀美 赵海荣 |
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| 作者单位： | 大理大学昆虫生物医药研究院云南省昆虫生物医药研发重点实验室;药用特种昆虫开发国家地方联合工程研究中心;大理大学中国西南药用昆虫及蛛形类资源开发利用2011协同创新中心 |
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| 基金项目： | 国家自然科学基金资助项目：景颇族传统昆虫药物胡蜂蜂毒对大鼠MCAO/R后BBB的保护作用及其潜在机制探索（81703742）；云南省应用基础研究重点项目：胡蜂蜂毒抗脑缺血活性及相关物质基础比较研究（2017FA050） |
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| 摘 要： | 目的研究膜翅目昆虫提取物Ento-Ⅱ涂膜剂的镇痛及活血化瘀作用,为相关药物的开发提供科学依据。方法采用经典热板法和扭体法作为镇痛实验模型,观察Ento-Ⅱ涂膜剂对小鼠的镇痛作用;大鼠sc大剂量盐酸肾上腺素后,施以冰水浸泡制备急性血瘀模型,采用线栓法复制大鼠局灶性脑缺血再灌注损伤模型,测定血液流变学相关指标。结果在镇痛实验中,与对照组比较,Ento-Ⅱ涂膜剂20、10、5 mg/kg能显著延长小鼠给药后30、60、90 min的痛阈值,明显减少小鼠15 min内的扭体次数,显著延长小鼠扭体的潜伏期(P0.01)。在血瘀合并脑缺血实验中,与模型组比较,Ento-Ⅱ涂膜剂6.67、3.33、1.67 mg/kg组24 h时大鼠神经功能评分和全血黏度显著降低(P0.01);3.33 mg/kg组大鼠血浆黏度和红细胞聚集指数显著降低(P0.05);6.67、3.33 mg/kg组大鼠卡松黏度显著降低(P0.01)。结论 Ento-Ⅱ涂膜剂具有明显的镇痛作用和活血化瘀作用。
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| 关 键 词： | 膜翅目昆虫 Ento-II涂膜剂 镇痛 脑缺血 活血化瘀 穴位给药 |
| 收稿时间： | 2018/1/7 0:00:00 |
Exploration of Ento-II plastic on analgesic and promoting blood circulation and removing stasis |
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| ZHANG Zhi-xue,HUANG Xi,LI Yue,YANG Zhi-bin,HE Ya-nan,WU Xiu-mei and ZHAO Hai-rong.Exploration of Ento-II plastic on analgesic and promoting blood circulation and removing stasis[J].Chinese Traditional and Herbal Drugs,2018,49(9):2108-2113. |
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| Authors: | ZHANG Zhi-xue HUANG Xi LI Yue YANG Zhi-bin HE Ya-nan WU Xiu-mei and ZHAO Hai-rong |
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| Institution: | Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Institute of Entomoceutics Research, Dali University, Dali 671000, China;National-Local Joint Engineering Research Center of Entomoceutics, Dali 671000, China,Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Institute of Entomoceutics Research, Dali University, Dali 671000, China;National-Local Joint Engineering Research Center of Entomoceutics, Dali 671000, China,Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Institute of Entomoceutics Research, Dali University, Dali 671000, China;Yunnan Provincial 2011 Collaborative Innovation Center for Entomoceutics, Dali University, Dali 671000, China;National-Local Joint Engineering Research Center of Entomoceutics, Dali 671000, China,Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Institute of Entomoceutics Research, Dali University, Dali 671000, China;Yunnan Provincial 2011 Collaborative Innovation Center for Entomoceutics, Dali University, Dali 671000, China;National-Local Joint Engineering Research Center of Entomoceutics, Dali 671000, China,Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Institute of Entomoceutics Research, Dali University, Dali 671000, China;Yunnan Provincial 2011 Collaborative Innovation Center for Entomoceutics, Dali University, Dali 671000, China,Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Institute of Entomoceutics Research, Dali University, Dali 671000, China;Yunnan Provincial 2011 Collaborative Innovation Center for Entomoceutics, Dali University, Dali 671000, China;National-Local Joint Engineering Research Center of Entomoceutics, Dali 671000, China and Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Institute of Entomoceutics Research, Dali University, Dali 671000, China;Yunnan Provincial 2011 Collaborative Innovation Center for Entomoceutics, Dali University, Dali 671000, China;National-Local Joint Engineering Research Center of Entomoceutics, Dali 671000, China |
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| Abstract: | |
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| Keywords: | hymenopteran Ento-II plastic analgesic effect cerebral ischemia activating blood and resolving stasis acupoint drug administration |
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