| 羧甲基葡聚糖抗肿瘤作用及其机制的研究进展 |
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| 引用本文： | 马璐,陈远才,熊明洲,王旭德,张雨蒙,赵余庆. 羧甲基葡聚糖抗肿瘤作用及其机制的研究进展[J]. 中草药, 2018, 49(11): 2692-2697 |
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| 作者姓名： | 马璐 陈远才 熊明洲 王旭德 张雨蒙 赵余庆 |
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| 作者单位： | 沈阳药科大学;珠海天香苑生物科技发展股份有限公司;沈阳药科大学基于靶点的药物设计与研究教育部重点实验室 |
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| 基金项目： | 辽宁省教育厅一般项目（L2015522）；沈阳药科大学科研专项基金（QNJJ2014504） |
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| 摘 要： | D-葡聚糖是一类免疫多糖,可调节机体免疫力,是一种重要的生物效应调节剂。羧甲基葡聚糖(carboxymethylated glucan,CMG)是D-葡聚糖的羧甲基衍生物,具有良好的水溶性和免疫活性。因此,在抗肿瘤治疗中具有广阔的应用前景。对CMG的抗肿瘤作用及其机制方面的研究进展进行综述,为CMG作为防治抗肿瘤药物的开发利用提供科学依据。
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| 关 键 词： | 羧甲基葡聚糖 抗肿瘤 免疫活性 作用机制 生物效应调节剂 |
| 收稿时间： | 2017-12-10 |
Research progress on antitumor effect and mechanism of carboxymethyl-glucan |
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| MA Lu,CHEN Yuan-cai,XIONG Ming-zhou,WANG Xu-de,ZHANG Yu-meng and ZHAO Yu-qing. Research progress on antitumor effect and mechanism of carboxymethyl-glucan[J]. Chinese Traditional and Herbal Drugs, 2018, 49(11): 2692-2697 |
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| Authors: | MA Lu CHEN Yuan-cai XIONG Ming-zhou WANG Xu-de ZHANG Yu-meng ZHAO Yu-qing |
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| Affiliation: | Shenyang Pharmaceutical University, Shenyang 110016, China,Zhuhai Tianxiang Yuan Biological Technology Development Co., Ltd., Zhuhai 519185, China,Zhuhai Tianxiang Yuan Biological Technology Development Co., Ltd., Zhuhai 519185, China,Shenyang Pharmaceutical University, Shenyang 110016, China,Shenyang Pharmaceutical University, Shenyang 110016, China and Shenyang Pharmaceutical University, Shenyang 110016, China;Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | D-glucan, an immune polysaccharide, is one kind of vital biological response modifiers (BRMs) which has the function of immune regulation. Carboxymethyl-glucan (CMG) is a water-soluble derivative of D-glucan that possesses excellent immunocompetent and water-solubility. Therefore, it has broad application prospects in anticancer therapy. The research progress of antitumor effect and mechanism of CMG was reviewed in this paper, which provides a scientific basis for the development and utilization of CMG as a candidate for the prevention and treatment of cancer. |
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| Keywords: | carboxymethyl-glucan (CMG) antitumor immunocompetent mechanism biological response modifier |
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