耐碳青霉烯类肺炎克雷伯菌相关危险因素及防治研究进展

碳青霉烯类药物的不合理使用,导致碳青霉烯类药物耐药的菌株数量激增。碳青霉烯类耐药菌株中,耐碳青霉烯类肺炎克雷伯菌占据重要比例。耐碳青霉烯类肺炎克雷伯杆菌自1997年被首次报道后,至今在全球多个国家均有报道,有些地区甚至出现了暴发流行。对比前几年细菌耐药监测数据,我国耐碳青霉烯类肺炎克雷伯杆菌的检出率呈不断上升趋势。耐碳青霉烯类肺炎克雷伯菌与碳青霉烯类敏感肺炎克雷伯菌相比,具有更高的致死率。本文就流行病学现状、相关危险因素、防治措施方面对耐碳青霉烯类肺炎克雷伯菌的研究进展进行综述。

Research progress of relevant risk factors of carbapenems-resistant klebsiella pneumoniae and its prevention and treatment

The unreasonable use of carbapenems has led to an explosion in the number of resistant strains of carbapenems.Among carbapenems-resistant strains,carbapenems-resistant Klebsiella pneumoniae accounts for a significant proportion.Carbapenems-resistant Klebsiella pneumoniae has been reported in many countries around the world since it was first reported in 1997.Outbreaks have appeared in some areas even.Compared with the previous years,the data of bacterial resistance surveillance showed that the detection rate of carbapenems-resistant Klebsiella pneumoniae in China was on an upward trend.Carbapenems-resistant Klebsiella pneumoniae has a higher lethality than carbapenems-sensitive Klebsiella pneumoniae.In this paper,the progress of studies on the current status of epidemiology,related risk factors,prevention and treatment measures of carbapenems-resistant Klebsiella pneumoniae are reviewed.