| 柯拉斯那沉香中的1个新倍半萜 |
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| 引用本文： | 王佩,康科星,孔凡栋,周丽曼,朱国鹏,戴好富,梅文莉. 柯拉斯那沉香中的1个新倍半萜[J]. 中草药, 2018, 49(19): 4480-4483 |
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| 作者姓名： | 王佩 康科星 孔凡栋 周丽曼 朱国鹏 戴好富 梅文莉 |
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| 作者单位： | 中国热带农业科学院热带生物技术研究所/农业部热带作物生物学与遗传资源利用重点实验室;海南大学热带农林学院 |
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| 基金项目： | 现代农业产业技术体系建设专项资金资助（CARS-21）；中国热带农业科学院院级创新团队南药产业技术创新团队（17CXTD-15）；海南自然科学基金创新研究团队项目（2017CXTD020）；中国热带农业科学院热带生物技术研究所基本科研业务费（1630052016008） |
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| 摘 要： | 目的研究柯拉斯那沉香Aquilaria crassna的化学成分。方法采用多种柱色谱对柯拉斯那沉香的化学成分进行分离纯化;通过波谱数据结合理化性质进行化合物结构鉴定;采用p NPG法对所得化合物的α-葡萄糖苷酶抑制活性进行测试。结果从柯拉斯那沉香的醋酸乙酯提取物中分离得到1个新的倍半萜类化合物和2个已知色原酮类化合物,分别鉴定为柯拉斯那酸甲酯(1)、8-氯-6-羟基-2-(2-苯乙基)色酮(2)、8-氯-6-羟基-2[2-(4-甲氧基)苯乙基]色酮(3)。结论化合物1为新化合物,命名为柯拉斯那酸甲酯。活性测试结果表明化合物1具有α-糖苷酶抑制活性,半数抑制浓度(IC50)值为121.8μg/mL。
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| 关 键 词： | 沉香 柯拉斯那沉香 倍半萜 色酮 柯拉斯那酸甲酯 α-葡萄糖苷酶 |
| 收稿时间： | 2018-05-31 |
A new sesquiterpenoid of agarwood from Aquilaria crassna |
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| WANG Pei,KANG Ke-xing,KONG Fan-dong,ZHOU Li-man,ZHU Guo-peng,DAI Hao-fu and MEI Wen-li. A new sesquiterpenoid of agarwood from Aquilaria crassna[J]. Chinese Traditional and Herbal Drugs, 2018, 49(19): 4480-4483 |
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| Authors: | WANG Pei KANG Ke-xing KONG Fan-dong ZHOU Li-man ZHU Guo-peng DAI Hao-fu MEI Wen-li |
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| Affiliation: | Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China,Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China,Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China,Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China,Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China,Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China and Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China |
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