| 黄花蒿中1个新的香豆素苷类化合物 |
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| 引用本文： | 王倩,侯国梅,李丹毅,李占林.黄花蒿中1个新的香豆素苷类化合物[J].中草药,2018,49(13):2953-2958. |
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| 作者姓名： | 王倩 侯国梅 李丹毅 李占林 |
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| 作者单位： | 沈阳药科大学基于靶点的药物设计与研究教育部重点实验室;沈阳药科大学中药学院 |
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| 摘 要： | 目的研究黄花蒿Artemisia annua全草大极性部位的化学成分。方法采用Sephadex LH-20柱色谱、硅胶柱色谱、ODS柱色谱和制备薄层色谱等方法进行分离纯化,根据波谱数据确定化合物的结构。结果从黄花蒿70%乙醇冷浸提取物的甲醇可溶部位中共分离得到14个化合物,分别鉴定为黄花蒿苷A(1)、东莨菪苷(2)、2,4-二羟基-6-甲氧基苯乙酮-4-O-β-D-吡喃葡萄糖苷(3)、咖啡酸甲酯(4)、水杨酸(5)、阿魏酸(6)、香草酸(7)、2,4-二羟基-6-甲氧基苯乙酮(8)、高圣草酚(9)、棕鳞矢车菊黄酮素(10)、penduletin(11)、甲氧基寿菊素(12)、圣草酚(13)和(R)-15,16-didehydrocoriolic acid(14)。结论化合物1为未见文献报道的新香豆素苷;化合物14为首次从蒿属植物中分离得到;化合物9为首次从黄花蒿中得到。
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| 关 键 词： | 黄花蒿 香豆素 黄酮类 黄花蒿苷A 高圣草酚 |
| 收稿时间： | 2018/4/17 0:00:00 |
A new coumarin glycoside isolated from Artemisia annua |
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| WANG Qian,HOU Guo-mei,LI Dan-yi and LI Zhan-lin.A new coumarin glycoside isolated from Artemisia annua[J].Chinese Traditional and Herbal Drugs,2018,49(13):2953-2958. |
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| Authors: | WANG Qian HOU Guo-mei LI Dan-yi and LI Zhan-lin |
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| Institution: | Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China,Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China,School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China and Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | |
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| Keywords: | Artemisia annua L coumarin flavonoid artemisiannuside A homoeriodictyol |
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