| 基于中医方证代谢组学的中药质量标志物发现研究 |
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| 引用本文： | 闫广利,孙晖,张爱华,韩莹,王喜军. 基于中医方证代谢组学的中药质量标志物发现研究[J]. 中草药, 2018, 49(16): 3729-3734 |
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| 作者姓名： | 闫广利 孙晖 张爱华 韩莹 王喜军 |
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| 作者单位： | 黑龙江中医药大学国家中医药管理局中医方证代谢组学研究中心/国家中医药管理局中药血清药物化学重点研究室/中美中医方证代谢组学技术合作中心 |
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| 摘 要： | 中药质量是影响中医药传承和发展的重要因素,然而由于中药成分的复杂性和复方应用的特殊性,现今的中药质量标准存在难以保障临床疗效的问题。刘昌孝院士提出中药质量标志物的概念和基本属性,为中药质量标准研究指明了方向。中医方证代谢组学是整合了中药血清药物化学与代谢组学技术,在方证对应并显效的情况下,发现与临床疗效相关、体现方剂配伍、可追溯体内代谢和制备过程的中药药效物质基础的研究策略,是发现中药质量标志物的有效方法。利用中医方证代谢组学方法已经对茵陈蒿汤、六味地黄丸等方剂及男仕胶囊、AS1350等中药保健品质量标志物的发现研究进行了探索。
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| 关 键 词： | 中药质量标志物 中医方证代谢组学 中药方剂 中药复方保健品 药效物质基础 |
| 收稿时间： | 2018-04-17 |
Discovery of quality markers of Chinese materia medica based on Chinmedomics |
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| YAN Guang-li,SUN Hui,ZHANG Ai-hu,HAN Ying and WANG Xi-jun. Discovery of quality markers of Chinese materia medica based on Chinmedomics[J]. Chinese Traditional and Herbal Drugs, 2018, 49(16): 3729-3734 |
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| Authors: | YAN Guang-li SUN Hui ZHANG Ai-hu HAN Ying WANG Xi-jun |
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| Affiliation: | Sino-US Chinmedomics Technology Cooperation Center, Key Laboratory of Serum Pharmacochemistry of TCM, Research Center of Chinmedomics, Heilongjiang University of Chinese Medicine, Harbin 150040, China,Sino-US Chinmedomics Technology Cooperation Center, Key Laboratory of Serum Pharmacochemistry of TCM, Research Center of Chinmedomics, Heilongjiang University of Chinese Medicine, Harbin 150040, China,Sino-US Chinmedomics Technology Cooperation Center, Key Laboratory of Serum Pharmacochemistry of TCM, Research Center of Chinmedomics, Heilongjiang University of Chinese Medicine, Harbin 150040, China,Sino-US Chinmedomics Technology Cooperation Center, Key Laboratory of Serum Pharmacochemistry of TCM, Research Center of Chinmedomics, Heilongjiang University of Chinese Medicine, Harbin 150040, China and Sino-US Chinmedomics Technology Cooperation Center, Key Laboratory of Serum Pharmacochemistry of TCM, Research Center of Chinmedomics, Heilongjiang University of Chinese Medicine, Harbin 150040, China |
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| Abstract: | |
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| Keywords: | quality marker (Q-marker) of Chinese materia medica Chinmedomics Chinese materia medica formula Chinese materia medica health products pharmacodynamic material basis |
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