番荔枝子中番荔枝内酯类化学成分研究

目的研究番荔枝Annona squamosa种子的化学成分。方法运用渗漉、萃取、柱色谱等方法进行分离和纯化,并结合化合物的理化性质及紫外、核磁、质谱数据进行结构鉴定。结果从番荔枝种子醋酸乙酯部位分得7个番荔枝内酯类化合物,分别鉴定为3-[7-[5-[1,4-二羟基-4-[5-(1-羟基十三烷基)-2-呋喃基]丁基]四氢-2-呋喃基]-2-羟基庚基]-5-甲基-2(5H)-呋喃酮(1)、3-[9-[5-(1-羟基-4-十七烯基)四氢-2-呋喃基]羟基壬基]-5-甲基-2(5H)-呋喃酮(2)、bullatalicin(3)、番荔枝塔宁A(4)、番荔枝塔宁D(5)、泡番荔枝辛(6)、10-羟基-巴婆双呋内酯(7)。结论化合物1和2为新化合物,分别命名为泡泡素I和索拉宁B。

Annonaceous acetogenins from seeds of Annona squamosa

Objective To study the chemical composition from the seeds of Annona squamosa.Methods The components of annonaceous acetogenins from the seeds of A. squamosa were isolated and purified by extracting and chromatography separation. The structures of the compounds were identified by their physicochemical properties, UV, NMR, and mass spectrometry data.Results Seven annonaceous acetogenins were isolated from the ethyl acetate extract of the seeds from A.squamosa. They are 3-[7-[5-[1,4-dihydroxy-4-[5-(1-hydroxytridecyl)-2-furanyl] butyl] tetrahydro-2-furanyl]-2-hydroxyheptyl]-5-methyl-2(5H)-furanone (1), 3-[9-[5-(1-hydroxy-4-heptadeceneyl) tetrahydro-2-furanyl] hydroxynonyl]-5-methyl-2 (5H)-furanone (2), bullatalicin (3), squamostatin A (4), squamostatin D (5), bullatacin (6), and 10-hydroxyasimicin (7).Conclusion Compounds 1 and 2 are two new compounds, named as trilobalicin I (1) and D20-solamin B (2), respectively.