| 少腹逐瘀凝胶贴膏剂基质处方优化及体外透皮特性研究 |
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| 引用本文： | 张莹莹,刘伟,周文杰,韩丽,杨荣平. 少腹逐瘀凝胶贴膏剂基质处方优化及体外透皮特性研究[J]. 中草药, 2018, 49(18): 4284-4292 |
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| 作者姓名： | 张莹莹 刘伟 周文杰 韩丽 杨荣平 |
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| 作者单位： | 成都中医药大学药学院中药材标准化教育部重点实验室四川省中药资源系统研究与开发利用重点实验室-省部共建国家重点实验室培育基地;天圣制药集团股份有限公司;西南大学 |
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| 基金项目： | 重庆市科委应用开发重大项目（cstc2014yykfC10006） |
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| 摘 要： | 目的通过Plackett-Burman联用Box-Behnken响应面法优化少腹逐瘀凝胶贴膏剂基质处方并对其体外透皮特性进行研究。方法在预实验基础上,采用Plackett-Burman设计联用Box-Behnken响应面法,以外观性状、初黏力、持黏力和剥离强度为综合指标优化最优处方,采用改良Franz扩散池法,以阿魏酸、芍药苷、异鼠李素-3-O-新橙皮苷、香蒲新苷为评价指标,考察不同用量氮酮促渗剂对凝胶贴膏体外透皮渗透量的影响。结果凝胶贴膏最优处方为Viscomate~(TM) NP-700-酒石酸-高岭土(2.42∶0.16∶0.96),3%氮酮对指标成分促渗效果良好,阿魏酸、芍药苷、异鼠李素-3-O-新橙皮苷、香蒲新苷体外透皮速率依次为6.889 4、1.917 4、0.842 0、0.893 7μg/(cm~2·h)。结论制备的少腹逐瘀凝胶贴膏膏体均匀,敷贴无残留,具有较好的释药性和透皮性,透皮行为符合零级动力学方程。
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| 关 键 词： | 凝胶贴膏剂 Plackett-Burman Box-Behnken 氮酮 透皮吸收 阿魏酸 芍药苷 异鼠李素-3-O-新橙皮苷 香蒲新苷 |
| 收稿时间： | 2018-04-20 |
Optimization of matrix formulation for Shaofu Zhuyu Cataplasm and research on its transdermal permeability in vitro |
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| ZHANG Ying-ying,LIU Wei,ZHOU Wen-jie,HAN Li and YANG Rong-ping. Optimization of matrix formulation for Shaofu Zhuyu Cataplasm and research on its transdermal permeability in vitro[J]. Chinese Traditional and Herbal Drugs, 2018, 49(18): 4284-4292 |
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| Authors: | ZHANG Ying-ying LIU Wei ZHOU Wen-jie HAN Li YANG Rong-ping |
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| Affiliation: | Key Laboratory of Standardization of Chinese Herbal Medicine of Ministry of Education;Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,Key Laboratory of Standardization of Chinese Herbal Medicine of Ministry of Education;Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,Tiansheng Pharmaceutical Group Co., Ltd., Chongqing 400065, China,Key Laboratory of Standardization of Chinese Herbal Medicine of Ministry of Education;Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China and Key Laboratory of Standardization of Chinese Herbal Medicine of Ministry of Education;Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province-Key Laboratory Breeding Base of Co-founded by Sichuan Province and MOST, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Southwest University, Chongqing 400715, China |
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| Abstract: | |
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| Keywords: | Shaofu Zhuyu Cataplasm Plackett-Burman Box-Behnken azone transdermal absorption ferulic acid paeoniflorin isorhamnetin-3-O-neohesperidin typhaneoside |
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