| 设计空间法优化红花温浸提取工艺 |
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| 引用本文： | 陈柽,李冰韶,王永洁,刘鑫,刘欣妍,赵颖,吴清.设计空间法优化红花温浸提取工艺[J].中草药,2018,49(19):4544-4551. |
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| 作者姓名： | 陈柽 李冰韶 王永洁 刘鑫 刘欣妍 赵颖 吴清 |
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| 作者单位： | 北京中医药大学中药学院 |
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| 摘 要： | 目的基于质量源于设计(quality by design,Qb D)理念,建立红花温浸提取工艺的设计空间并进行验证。方法以红花为模型药,通过查阅文献及前期研究经验获得关键评价指标;采用鱼骨图结合失效模式与效应分析(failure mode effects analysis,FMEA)确定影响红花温浸提取过程的关键工艺参数(critical process parameters,CPPs),通过Box-Behnken实验设计建立了CPPs与关键评价指标的数学模型。结果以总黄酮提取量、羟基红花黄色素A(HSYA)提取量以及总固体提取量为关键评价指标,通过鱼骨图结合FMEA确定了加水倍量、提取温度、提取时间及提取次数为CPPs。Box-Behnken实验方差分析结果显示所建立模型的P值均小于0.000 1,表明所建立的模型具有较好的预测能力,得到推荐的操作空间为提取次数2次,提取时间2.5 h,加水倍量为23.5～25 mL/g生药,提取温度65～71℃。结论红花温浸提取设计空间的建立,提高了提取工艺参数与提取液质量之间的关联性,为设计空间法在中药领域的适用性提供了参考。
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| 关 键 词： | 设计空间 羟基红花黄色素A 总黄酮 关键工艺参数 风险评估 |
| 收稿时间： | 2018/5/29 0:00:00 |
Design space method for optimizing extraction process of Carthami Flos |
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| CHEN Cheng,LI Bing-shao,WANG Yong-jie,LIU Xin,LIU Xin-yan,ZHAO Ying and WU Qing.Design space method for optimizing extraction process of Carthami Flos[J].Chinese Traditional and Herbal Drugs,2018,49(19):4544-4551. |
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| Authors: | CHEN Cheng LI Bing-shao WANG Yong-jie LIU Xin LIU Xin-yan ZHAO Ying and WU Qing |
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| Institution: | School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 102488, China,School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 102488, China,School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 102488, China,School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 102488, China,School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 102488, China,School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 102488, China and School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 102488, China |
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| Abstract: | |
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| Keywords: | design space HSYA total flavonoid critical process parameters risk assessment |
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