MicroRNA和雪旺细胞自噬与周围神经再生修复的研究进展

正周围神经损伤会使神经支配区域的运动、感觉机能下降和缺失,严重影响生产和生活质量。现代显微外科技术的应用已大大提高了修复效果,但由于周围神经的特殊结构和功能,目前的修复技术对于神经功能的恢复效果仍然有限,这引起了研究者们对于周围神经损伤后再生修复机制的探索。周围神经损伤后,损伤处残存雪旺细胞(Schwann cells)的数量和增殖分化能力是影响神经再生修复的关键因素[1]。在周围神经损伤后的雪旺细胞内发现大量溶

Relationship between microRNAs and autophagy in Schwann cells during peripheral nerve regeneration and repair

The survival, proliferation and differentiation of Schwann cells are the decisive factors of peripheral nerve regeneration. Autophagy is an important mechanism to regulate homeostasis and make Schwann cells pass the stress period, thus providing protection for the survival of Schwann cells and becoming a key factor on nerve regeneration. Recent studies indicate that a number of microRNAs participate in the activity of Schwann cells and play an important regulatory role in the process of nerve injury repair. In our studies, we found that microRNAs played an important regulatory role in autophagy at the early stage of nerve injury. Therefore, the relationship between microRNAs and autophagy in Schwann cells during the regeneration and repair of peripheral nerve injury is described in this paper.